DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and ces2b

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	1068	Identity:	264/1068 - (24%)
Similarity:	406/1068 - (38%)	Gaps:	287/1068 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MKLREAPKQSRVIGDITTTIQPDSDPGRSIG--HQALRRAKAP--------PPSLELHFRQNLNK 101
            :::|:..::  ::||....|     |.|...  |   |.|.||        |||:....|.:.:.
Zfish   398 IRIRDGFRE--MLGDFMFNI-----PARQTASYH---RDAGAPVYVYEFRHPPSVLQRKRPSFSG 452

  Fly   102 LFAGDETTHV-GHTNATDNTTAAVLATDE------------GSSEHE-----PSTTHHPERRHVV 148
            ...|||...| |:..:......|...:||            |:..|.     |..|..||    .
Zfish   453 SDHGDEIVFVFGYCFSEGPIGMAENLSDEEDELCRTTMAYWGNFAHTGNPNGPGLTSWPE----F 513

  Fly   149 PDKLQY---------------------TQE-------------IQVKQGRLMGITRRFQVTSGLR 179
            .|:.:|                     ||.             :..|.|.|.|   .:.:..|..
Zfish   514 GDEAEYLSIGLDPKASTDLKGKHFTFVTQTFPRILSERKEGPVVNTKLGSLRG---SYMMAKGKD 575

  Fly   180 QV-DQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKH 243
            .| ..:..:|:|::|.|..|..||.....|||::.|...||:|      |.|  .|.|     ..
Zfish   576 SVISSYFAIPFAKSPVGPLRLTPPQPADAWQGVRDATKQPPMC------LQP--KEVM-----VD 627

  Fly   244 LSRLLPYLRTE----SEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSY 304
            |...:| |:||    ||||||||:|.|.:...:  |:..|:|::||....:.|.:.:|...|::|
Zfish   628 LLATMP-LKTEFPEVSEDCLYLNIYTPSKPGDN--KKLPVMVWIHGGGLAFGSASIFDAHALAAY 689

  Fly   305 GEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGA 369
            .:::||.|.||||:|||.... |.|...||.||||:|||.|::|||.:||||...||:.|.|.|.
Zfish   690 QDIVVVMVQYRLGLLGFFSTG-DEHAPGNYGLLDQVAALQWVQENIHSFGGDPGSVTVFGESAGG 753

  Fly   370 ACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLD 434
            ...:.|::||:::.||||||..||:|..:...|...|.....:.:...|.::...:      ::|
Zfish   754 VSASLLVLSPLSANLFHRAIAESGTAAMNAIMSPDPLSTARSLGNVSGCDISSTKK------IVD 812

  Fly   435 CLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHT 499
            |:.....:|||.|  |..|.....|..|||..:|....:::  .::.||:..|:.|:|:.:...|
Zfish   813 CVMQMTEEDILKI--AREQVLLRFGVTVDGQFLPKSVDELL--QSQEFSKVPLMTGVTDDDGGFT 873

  Fly   500 LAALALEEGLREN-ERDNLLRFYMQSRFDIR-PDLALAATLKKYQDMYNNPIKATNLEHRDVVLD 562
            |.......|.|:. .:|.::.|.....:|:: |.|| ...||:|.....:.||.     ||...:
Zfish   874 LPEFIAPPGWRDGMTKDQIMPFLPTYNYDLQDPGLA-EIVLKEYLGATTDKIKI-----RDGFRE 932

  Fly   563 ILSDARVVGPLLQTGMFHADVNRRNYMYVFGH-----NSATGPFAHLPHSIMGEELAFIFGAPLA 622
            |:.|.....|..:...:|.|.....|||.|.|     .:....|....|   |:||.|:||....
Zfish   933 IVGDFFFNLPARKLANYHRDTGAPVYMYEFQHPAYIFQNKRPSFVGCDH---GDELLFVFGYCFG 994

  Fly   623 AAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQ 687
            .......|..:.:|:.|.:..||||.||.:||||..|  |:             ::||::...|:
Zfish   995 NGHIKVEGELSKEEQELCKTTMAYWGNFARTGNPNGP--GL-------------VEWPKYGAEAE 1044

  Fly   688 AYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQEVITGHMSKYGPRDHGAED 752
             ||.||:.......::..:.:|..::||..:.:                            ..|.
Zfish  1045 -YLGIGLEQKSSKNFKGNHFHFMIEKLPQIIKE----------------------------WKEG 1080

  Fly   753 PVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAP---PTFGHVHKMQGGSDFEDLVTSTNSLES 814
            ||...||    .||.|...:.:..:|...:....|   |..|.:...:
Zfish  1081 PVVETKL----GSLRGAFLTVKGKDTIVNSYLGVPFAKPPVGPLRLAR----------------- 1124

  Fly   815 GEDHPQAPPETVAKSEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPAPKLGGTILS 879
                |||..:.....:||.|                 ....|::|:.....|.|         ||
Zfish  1125 ----PQAAEKWQGVRDATKQ-----------------PRMCLQERQMTVTELEF---------LS 1159

  Fly   880 YDGANDEELKRCSKSRDGDDSFVLEMTRKSNTYEAIKTGQRSLSCSTVDTHTKVCEWMSSQEAPK 944
            .    |.|:...|     :|...|      |.|..:|.||.       |....|..|:..
Zfish  1160 M----DVEVPEVS-----EDCLYL------NIYTPVKPGQG-------DKKLPVMVWIHG----- 1197

  Fly   945 SG-SFNTATPPPQPILSDGRLIIC-QDIEVADAALLIPQHM-----------HEPQHYEMLLQRQ 996
            .| |..:|:      :.||.::.. ||:.|    :||...:           |.|.:|..|
Zfish  1198 GGLSLGSAS------MYDGSVLAAYQDVVV----VLIQYRLGLLGFLSTGDEHAPGNYGFL---- 1248

  Fly   997 HSALTEPSDEILQQQYPLRNHSHSHSDP 1024
                    |::...|:...|......||
Zfish  1249 --------DQVAALQWVQENIHSFGGDP 1268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	175/602 (29%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	59/144 (41%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613	31/154 (20%)
		COesterase	553..1065	CDD:306613	172/566 (30%)
		COesterase	1079..1592	CDD:306613	56/290 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910