Protein Alignment Nlg1 and nlgn4xa

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_021330915.1
• Gene: nlgn4xa / 561122
• ZFINID: ZDB-GENE-100309-2
• Length: 844
• Species: Danio rerio
• Alignment Length: 827
• Identity: 235/827 - (28%)
• Similarity: 376/827 - (45%)
• Gaps: 148/827 - (17%)

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222
            :....|:|.|:..... ...|..|:|:||:|||..|||.|||.||..|:.|.|::.|....||||
Zfish    45 VTTNYGKLRGLKTPLP-NEILGPVEQYLGIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVCP 108

  Fly   223 QKLPD-------LSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVP-------------- 266
            |.|.|       |....:.|        |..::.|::.:||||||||:|||
Zfish   109 QFLEDRFLLNDMLPVWFTAN--------LDTVVTYVQDQSEDCLYLNIYVPTEDVGANKGDDFTN 165

  Fly   267 ---------HEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFL 322
                     |:|....|    |:||:||.|:...:||..|||:|:|||.|||||:||||||||||
Zfish   166 NEGGENKDIHDENGLRP----VMVYIHGGSYMEGTGNMIDGSILASYGNVIVVTLNYRLGVLGFL 226

  Fly   323 RPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHR 387
            .....|.. .||.|||||.||.||||||:||.||..|||:.|...||:||:.|.:|..:..||.:
Zfish   227 STGDQAAK-GNYGLLDQIQALRWIKENIQAFKGDPKRVTIFGSGAGASCVSLLTLSHYSEDLFQK 290

  Fly   388 AILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALT 452
            ||:.||:|:|.||.:.|..:.|..:|..:.|.:.:.::      |::||:::.|::::.......
Zfish   291 AIIQSGTALSSWAVNYQPAKYTRILAEKVGCNMLDSID------LVECLQNKNYKELIEQYITQA 349

  Fly   453 QFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA-LEEGLRENERD- 515
            ::..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|.:..:..:. .|:|:..|:.|
Zfish   350 KYHIAFGPVIDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGEGFKFVDGIVDSEDGVSANDFDF 412

  Fly   516 ------NLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILSDARVVGPL 573
                  :.|..|.:.:..:|..:..         ||.:.....|.| .|..::.:.:|.:.|.|.
Zfish   413 AVSDFVDHLYGYPEGKDTLRETIKF---------MYTDWADKENPETRRKTLVALFTDHQWVAPA 468

  Fly   574 LQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKL 638
            :.|...||......|.|.|.|:..:........|..|:|:.::||.|:.......:.|::..:.:
Zfish   469 VATADLHAQYGSPTYFYAFYHHCQSEMKPSWSDSAHGDEVPYVFGIPMLGPTDLFNCNFSKNDVM 533

  Fly   639 LSEAVMAYWTNFVKTGNPKAP----WKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVG 699
            ||..||.|||||.|||:|..|    .|.|....:..|    ::.|.::|.:.|.||:||:.|.|.
Zfish   534 LSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVAWSKYNPKDQLYLHIGLKPRVR 594

  Fly   700 YKYRQIYMNFWNKELP-----DELNQIAAIQEQLQKPGQEV----ITGHMSKYGPRDHGAEDPVR 755
            ..||...:.||.:.:|     :||.|..:...::  |.|:.    .|..:.|..|.
Zfish   595 DHYRATKVAFWLELVPHLHNINELFQYVSTTTKI--PPQDTTPFPYTKRLGKTWPS--------- 648

  Fly   756 TLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQ 820
                ..:.|.:. |..:.::|:                  .:.|:|..|  .|...:|:..|:
Zfish   649 ----TTRHPGVP-PANTKQTTD------------------QRKGNDLSD--DSAVVIETKRDY-- 686

  Fly   821 APPETVAKSEATMQLLIALITIIIVLNLLIYGT-FLLRQRRRRAKALPFPAPKLGGTILS-YDGA 883
                     ...:.:.||:...::.||:|.:.. :..:.:||.......|:|:......: ...|
Zfish   687 ---------STELSVTIAVGASLLFLNILAFAALYYKKDKRRHESNRRGPSPQRNSAPANVVANA 742

  Fly   884 NDEELKRCSKSRDGDDSFVLEMTRKSNTYEAIKTGQRSLSCSTVDTH 930
            ||      ......|:...|:|.::...:|      ....|.::..|
Zfish   743 ND------IAHLQSDELMSLQMKQQQMEHE------HHHECDSLQAH 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	197/594 (33%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:395084	197/594 (33%)