DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and nlgn2a

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_009301340.1	Gene:	nlgn2a / 556158	ZFINID:	ZDB-GENE-090918-2	Length:	828	Species:	Danio rerio

Alignment Length:	870	Identity:	251/870 - (28%)
Similarity:	383/870 - (44%)	Gaps:	168/870 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222
            :....|:|.||.:... ...|..|:|:||:|||.||.|:|||.||.||..||.::.|....||||
Zfish    49 VTTNYGKLRGIKKELN-NEILGPVEQYLGVPYATAPIGDRRFQPPEAPGSWQEVRNATQFAPVCP 112

  Fly   223 QK----LPDLSPHGSENMSRARHKHLSRLLP------------YLRTESEDCLYLNLYVPHEEPQ 271
            |.    ||::                  :||            |::.:||||||||:|||.|:..
Zfish   113 QNVHGVLPEI------------------MLPVWFTDSLDVAATYIQNQSEDCLYLNVYVPTEDGP 159

  Fly   272 STPK------------------QYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGV 318
            .|.|                  :..|::::||.|:...:||.:|.|||::||.|||||:||||||
Zfish   160 LTKKHDESTLNRPRDEDIRDRRKKPVMLFIHGGSYMEGTGNMFDASVLAAYGNVIVVTMNYRLGV 224

  Fly   319 LGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASG 383
            ||||... |.....||.|||||.||.|:.|||..||||..|:|:.|...||:|||.|::|..:.|
Zfish   225 LGFLSTG-DQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEG 288

  Fly   384 LFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIP 448
            ||.|||..||||:|.|:.|.|.|:.|..:|..:.|...|..:      |:||||.:.:::::...
Zfish   289 LFQRAIAQSGSAISSWSISYQPLKYTKILARKVGCTYGETAD------LVDCLRRKNFRELVDQD 347

  Fly   449 TALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTL--AALALEEGLRE 511
            ....::..:.||::||.|:|:.|..:|  ....|..||||.|:.:.|....:  .....|||:..
Zfish   348 IQPARYHIAFGPVMDGDVVPDDPEILM--QQGEFLNYDLLIGVNQGEGLKFVDDGGTESEEGISA 410

  Fly   512 NERDNLLRFYMQSRF------DIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILSDARV 569
            ...|..:..::.:.:      ||     |..|:|   .||.:.....|.| .|..:|.:.:|.:.
Zfish   411 AAFDYTISNFVDNLYGYPKGKDI-----LRETIK---FMYTDWADRDNGEMRRKTLLALFTDHQW 467

  Fly   570 VGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTV 634
            |.|.:.|...|||.....|.|.|.|:..|........:..|:|:.::||.|:..|......|::.
Zfish   468 VAPAIATAKLHADYQSPVYFYTFYHHCQTETRPEWADAAHGDEIPYVFGVPMIGATDLFPCNFSK 532

  Fly   635 QEKLLSEAVMAYWTNFVKTGNPKAP----WKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIP 695
            .:.:||..||.|||||.|||:|..|    .|.|....:..|    ::.|.:||.:.:.||:||:.
Zfish   533 NDIMLSAVVMTYWTNFAKTGDPNLPVPQDTKFIHTKPNRFE----EVIWTKFNSKDKQYLHIGLK 593

  Fly   696 PTVGYKYRQIYMNFWNKELPDELNQIAAIQEQL------QKPGQEVITGHMSKYGPRDHGAEDPV 754
            |.:...||...:.||.:.:|...|    :.|::      :.|.....|.|....|||.  ...|:
Zfish   594 PRIRDNYRANKVAFWLELVPHLHN----LHEEVFSTATTRLPPGTARTPHWKGQGPRT--TRHPI 652

  Fly   755 RTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHP 819
            .|.      ||...|..|.:             |.|                            |
Zfish   653 PTF------PSELDPDSSEQ-------------PRF----------------------------P 670

  Fly   820 QAPPETVAKSEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPAPKLGGTILSYDGAN 884
            ..|.:|...| ..:.:.:|:...::.||:|.:.....::.:|........:|:.|  :.:.|.|:
Zfish   671 PFPSDTRDYS-TELSVTVAVGASLLFLNILAFAALYYKRDKRHEMRRHRLSPQRG--VAANDLAH 732

  Fly   885 DEELKRCS---KSRDGDDSFVLEMTRKSNTYE---------AIKTGQRSLSCSTVDTHTKVCEWM 937
            .:|.:..|   |..:.|....:|..|..:...         |::.....:...|.:|.|.:...:
Zfish   733 SQEEEIMSLQMKHSEHDAHHDMEPLRPHDILRPACPPDYTLALRRAPDDVPLMTPNTITMIPSTI 797

  Fly   938 SSQEA-------PKSGSFNTATPPP 955
            :..:.       |.|...|...|.|
Zfish   798 TGMQPLHAFNTFPTSTGHNNTLPHP 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	204/598 (34%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	76/162 (47%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:306613	204/598 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.780