Protein Alignment Nlg1 and NLGN3

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 905
• Identity: 256/905 - (28%)
• Similarity: 394/905 - (43%)
• Gaps: 221/905 - (24%)

  Fly    59 IGDITTTIQPDSDPGRSIG------HQALRRA-KAPPPSLELHFRQNLNKLFAGDETTHVGHTNA 116
            :|..:.::.|....|||:.      ..|||.: :||.|::..||
Human     5 LGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHF--------------------- 48

  Fly   117 TDNTTAAVLATDEGSSEHEPSTTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSG-LRQ 180
                                                          |:|.|  .|..:.|. |..
Human    49 ----------------------------------------------GKLRG--ARVPLPSEILGP 65

  Fly   181 VDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARH-KHL 244
            |||:||:|||..|.|.:||:||..|..|.|::.|.|.||||||.:....|   |.|..... .:|
Human    66 VDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVP---EVMLPVWFTANL 127

  Fly   245 SRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYA------------------------------- 278
            ..:..|::..:|||||||:|||.|:.:...|:.|
Human   128 DIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDE 192

  Fly   279 ---------VLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANY 334
                     |:||:||.|:...:||..|||:|:|||.|||:|:|||:||||||.....|.. .||
Human   193 DIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAK-GNY 256

  Fly   335 ALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDW 399
            .|||||.||.|:.|||..||||..|:|:.|...||:||:.|.:|..:.|||.|||:.||||:|.|
Human   257 GLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSW 321

  Fly   400 AASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDG 464
            |.:.|.::.|..:|..:.|.:.:.|:      ::||||.:..::::.......::..:.||::||
Human   322 AVNYQPVKYTSLLADKVGCNVLDTVD------MVDCLRQKSAKELVEQDIQPARYHVAFGPVIDG 380

  Fly   465 HVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA-LEEGLR--------ENERDNLLRF 520
            .|||:.|..:|..  ..|..||::.|:.:.|....:..:. .|:|:.        .|..|||..
Human   381 DVIPDDPEILMEQ--GEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYG- 442

  Fly   521 YMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILSDARVVGPLLQTGMFHADVN 584
            |.:.:..:|..:..         ||.:.....|.| .|..::.:.:|.:.|.|.:.|...||...
Human   443 YPEGKDTLRETIKF---------MYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYG 498

  Fly   585 RRNYMYVFGHN------SATGPFAHLPHSIMGEELAFIFGAPLAAAGP---FPSGNYTVQEKLLS 640
            ...|.|.|.|:      .|....||      |:|:.::||.|:  .||   ||. |::..:.:||
Human   499 SPTYFYAFYHHCQSLMKPAWSDAAH------GDEVPYVFGVPM--VGPTDLFPC-NFSKNDVMLS 554

  Fly   641 EAVMAYWTNFVKTGNPK--APWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYR 703
            ..||.|||||.|||:|.  .|....||::.|..::  ::.|.::|.|.|.||:||:.|.|...||
Human   555 AVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFE--EVAWSKYNPRDQLYLHIGLKPRVRDHYR 617

  Fly   704 QIYMNFWNKELPDELN-----QIAAIQEQLQKPGQEVITGHMSKYGPRDHGAEDPVRTLKLLLQE 763
            ...:.||...:|...|     ...:...::..|.    |.|.|....|.:|     :|..  .:.
Human   618 ATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPD----TTHSSHITRRPNG-----KTWS--TKR 671

  Fly   764 PSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQAPPETVAK 828
            |::: |..|.|:    |:..:|            |..|...|:     :|:..|:
Human   672 PAIS-PAYSNEN----AQGSWN------------GDQDAGPLL-----VENPRDY---------- 704

  Fly   829 SEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPAPKLGGTILSYDGANDEEL 888
             ...:.:.||:...::.||:|.:.....|:.:||.:.|..|:|:.|........|.:|||
Human   705 -STELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELGAAPEEEL 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	205/615 (33%)
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	209/685 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694		15/76 (20%)