Protein Alignment Nlg1 and Ces2h

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001258974.1
• Gene: Ces2h / 436059
• MGIID: 3648740
• Length: 558
• Species: Mus musculus
• Alignment Length: 635
• Identity: 186/635 - (29%)
• Similarity: 294/635 - (46%)
• Gaps: 98/635 - (15%)

  Fly   107 ETTHVGHTNATDNTTAAVLATDEGSSEHEPSTTHHPERRHVVPDKLQYTQEIQVKQGRLMG-ITR 170
            |..|...|.||  ....:|...:|.....|..|.|                    .|:::| :..
Mouse     4 EQIHARLTTAT--CGLLLLLRVQGQDSTSPIRTTH--------------------TGQILGSLIH 46

  Fly   171 RFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSEN 235
            ...:..|   |..|||:|:|:.|.|..||.||..|.||.|::.....|.:|   |.|::.
Mouse    47 MKDLDVG---VHSFLGIPFAKPPVGPLRFAPPEPPEPWGGVRDGTSHPAMC---LQDITA----- 100

  Fly   236 MSRARHKHLSRLLPYLRTESEDCLYLNLYVPH--EEPQSTPKQYAVLVYLHGESFEWNSGNPYDG 298
            |:....|.|...||.. ..||||||||:|.|.  .|..:.|    |:|::||.|......:.|||
Mouse   101 MNMQAFKLLKLTLPPF-PMSEDCLYLNIYAPDHAHEGSNLP----VMVWIHGGSLVIGMASMYDG 160

  Fly   299 SVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLM 363
            |:|::...|:|||:.||||||||.... |.....|:..|||:|||.|:::||..|||:..|||:.
Mouse   161 SMLAAMENVVVVTIQYRLGVLGFFSTG-DERARGNWGYLDQVAALRWLQQNIAYFGGNPDRVTIF 224

  Fly   364 GHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAED 428
            |.|.|...|:.|:|||::.|||..||:.||.|:.....|..|..:...:|:...|      |..|
Mouse   225 GTSAGGTSVSSLVVSPMSQGLFRGAIMESGVALISSLISVSSDVVYQTVANLSGC------EQVD 283

  Fly   429 DDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITE 493
            .:.|::|||.:..::|:.|..|   |....| ||||..:|..|.::|.  :..|.....:.|:..
Mouse   284 SEALVNCLRGKSEEEIMAINKA---FKIIPG-IVDGIFLPRHPQELMA--SADFHPVPSIIGVNN 342

  Fly   494 SE-SYHTLAALALEEGLRENERDNLLRFYMQSRFD--IRPDLALAATLKKYQDMYNNPIKATNLE 555
            .| .:...:::::.:..:..:| .:::..:|.|..  :.|.......:::|.....:| :...::
Mouse   343 DEYGWIIPSSMSMIDSKKGMDR-QMVQAILQRRATQMMWPPEVSDLLMEEYMGDNEDP-QFLQVQ 405

  Fly   556 HRDVVLDILSDARVVGPLLQTGMF---HADVNRRNYMYVFGHNSATGPFAHLPH--SIMGEELAF 615
            .:    :::.|...|.|.||...|   ||.|    :.|.|.|..:....:...|  :..|:|:.|
Mouse   406 FK----EMMKDFTFVIPALQVAQFQRSHAPV----FFYEFQHRPSFFKDSKPSHVKADHGDEILF 462

  Fly   616 IFGAPLAAAGPFPSG---NYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDL 677
            ||.:       |..|   ::|.:|:|||..:|.||.||.:..||         ||..|.:
Mouse   463 IFRS-------FWGGTQVDFTEEEELLSRRMMKYWANFARQRNP---------NSEGLPY----- 506

  Fly   678 DWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQ 727
             ||.|::..| ||.:...|.||...:...:.||.|.||:::.::..|:::
Mouse   507 -WPMFDQDEQ-YLQLDTQPAVGRALKTRRLQFWTKTLPEKIQELKDIEDR 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	170/566 (30%)
Ces2h	NP_001258974.1	COesterase	30..537	CDD:395084	173/588 (29%)