Protein Alignment Nlg1 and Nlg4

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Alignment Length: 1416
• Identity: 364/1416 - (25%)
• Similarity: 534/1416 - (37%)
• Gaps: 484/1416 - (34%)

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222
            :|.:.|||.|:.........||.|:.|||:|||..||...||.|..||.||.|::|:....||||
  Fly    44 VQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCP 108

  Fly   223 QKLPDLSPHGS--ENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHG 285
            |:||::....:  |.|.:.|.::|.||||:|..:||||||||::.| ....:..|:..|:|::||
  Fly   109 QRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSP-VNAGANEKKLPVIVFIHG 172

  Fly   286 ESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFL--RPSIDAH-NIANYALLDQIAALHWIK 347
            |||||:||||||||||:|||||:|||:|||||:||||  .|:..|| .:|||.|:||:||||||:
  Fly   173 ESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQ 237

  Fly   348 ENIEAFGGDNSRVTLMGHSTGAACVNYLMVSP-VASGLFHRAILMSGSAMSDWAASNQSLQLTMQ 411
            :||:.||||.:.|||.||.|||||:||||.|| :..|||||||||||||.|.||.....:...::
  Fly   238 QNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIK 302

  Fly   412 IAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMG 476
            :|..:.|.:.:.:....:.: :||||....:|:.........|.||.||.|||.||  :|    |
  Fly   303 LAKEVNCTIPDDINRHHEQI-VDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVI--RP----G 360

  Fly   477 HYT------------------------------------------------EHF----------- 482
            |..                                                .:|
  Fly   361 HSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMG 425

  Fly   483 SRYDLLFGITESESYHTLAALALEEGLRENERDNLLRFYMQSRFDIRPDLALAATLKKYQD---M 544
            ..||:|||:...||....:|..::.|.....||.::|.|:::.::...:......:.:|.|   .
  Fly   426 GHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRT 490

  Fly   545 YNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHA---------------------------- 581
            ..:||..     ||..:..||||:.|.|:::.|...|
  Fly   491 SQHPINT-----RDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGS 550

  Fly   582 -DVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLA-AAGPFPSGNYTVQEKLLSEAVM 644
             ..:.|.|.|||.:.:..|.:.....::.||:|.:||||||. ....||. |||..|..||||||
  Fly   551 TQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQ-NYTKSETALSEAVM 614

  Fly   645 AYWTNFVKTGNPKAPWKGIFINSH---------ALEWDRY-DLDWPEFNRRAQAYLNIGIPPTVG 699
            .:||||.:||||         |.|         :.|.:|: .:.|..::...|.||.||:.|.:.
  Fly   615 IFWTNFARTGNP---------NEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIK 670

  Fly   700 YKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQEVITGHMSKYGPRDHG----AEDPVR----- 755
            ..:|...::.|.:.:|           :|.:.|.|.:....:.:  |:|.    .|.||:
  Fly   671 NHFRAHQLSIWLRLIP-----------ELHRAGMEDVIARHNLF--RNHDDMDLYEGPVKPDPFG 722

  Fly   756 ----------------TLKLLLQEPSL---AGPTQSGES--------TETAAENMYNAPPTFGHV 793
                            :.:|||.:..|   .|...:|.:        |.....|||......|..
  Fly   723 ISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGN 787

  Fly   794 HKMQGGSDFEDLV--TSTNSLESGEDHPQAPPETVAKSEATMQLLIALITIIIVLNLLIY-GTFL 855
            :...||......:  .|:::|.||.:     ....|.....:.:.||:...:::||:||: |.:.
  Fly   788 YSSSGGVFAPTTLANASSDTLASGFE-----AAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYY 847

  Fly   856 LRQRRRRAKALPFPAPKLGGTILSYDGANDEELKRCSKSRDGDDSFVLEMTRKSNTYEAIKTGQR 920
            .|.:.|                                         ||:......|:     ||
  Fly   848 QRDKTR-----------------------------------------LEVKTLQKQYQ-----QR 866

  Fly   921 SLSCSTVDTHTKVCEWMSSQEAPKSGSFNTATPPPQPILSDGRLIICQDIEVADAALLIPQHMHE 985
            ||                .|:.|.         ||:||                      :|
  Fly   867 SL----------------HQQVPY---------PPEPI----------------------KH--- 881

  Fly   986 PQHYEMLLQRQHSALTEPSDEILQQQYPLRNHSHSHSDPVDMILAADEQVTSFVHADDVDINVTS 1050
             .||.|                        .||.|.:                    :|.::|.|
  Fly   882 -AHYHM------------------------GHSQSSA--------------------NVIVDVES 901

  Fly  1051 RDDSDGLEVIPLTSAQQLELLRQRNYPKVLPTEQDLINSSYKRNSLPPQNFNAPLPPPRTISNTL 1115
            ..|..|...:.|.:|...                    ::...|.:.|       |||...|||
  Fly   902 HQDQAGQAAMLLQAAAAA--------------------AAAAANDVKP-------PPPHICSNT- 938

  Fly  1116 GRRRRDSSNITTSPLQVARDCGG--EDEDLKEPQITQNTLIVGPIVPKSPASSLK---------- 1168
            |.:::.         ||....||  .:..::..::|.:.|  |.:...:.:...:
  Fly   939 GMQQQQ---------QVGGGSGGALNNGGIEGSKVTTDNL--GNVTYSTSSKQQQQHQQQQQQQQ 992

  Fly  1169 ----RVKRM-----------------------PESSAMTALSGSFQSFEAVPPAHETTPPQGG-- 1204
                ::|.|                       ....|...:|||..|:.   |...|.|..||
  Fly   993 REHMQIKGMTGTQTFGRSGSGSGGGAGGGAGSASGGASVVVSGSSVSYN---PGMMTLPKSGGLH 1054

  Fly  1205 -----ERTECIYAIRPSPGSCSWAAPNGDLYAQPMKSSSRNSLIPRPTKPAESQSQATPAGPAGE 1264
                 .......|:..|.|..:            :..|..|.|:   |..|.....|......|.
  Fly  1055 HAATLNYARNTTALNMSGGGTA------------LVDSRGNVLL---TSTAVGPGMAGTGAGGGS 1104

  Fly  1265 SLG-----------STGMATASR------IPQLQRQASGKDLQA--------------------R 1292
            |.|           :.|:|.|.|      :.|.|:|......|:                    |
  Fly  1105 SGGGGGGDCMTLPRNLGLAAAGRHNPTTELQQYQQQQQSSKHQSNGAVLTGMQSHHIRGPRPPLR 1169

  Fly  1293 TATDNTAN------PLGC---------QPRTDSTISSGSSASYASTTDSSS 1328
            ||:..|.|      .:|.         ....|.|.|.|||:|..|:..|||
  Fly  1170 TASSTTTNSSSNNSAMGVAVGVGGGVGNMLLDQTPSGGSSSSGVSSAPSSS 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	235/659 (36%)
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	235/659 (36%)