DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Nlg3

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster

Alignment Length:	1080	Identity:	307/1080 - (28%)
Similarity:	468/1080 - (43%)	Gaps:	237/1080 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GDITTTIQPDSDPGRS----IGHQALRRAKAPPPSLELHFRQNLNKLFAGDETTHVGHTNATDNT 120
            |:::|:.:..|.....    ||..:...:..|..||.......|:...:...::....:.:..|:
  Fly    61 GNLSTSQKSPSSANNGGLVLIGSSSATSSSVPSLSLTSSSSAGLSSPGSSSSSSSSSTSTSGSNS 125

  Fly   121 TAAVLATDEGSSEHEPSTTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFL 185
            ..:...|...|:.:...:.:|.:    :|.:|. ::.|..:.|.:.|:..:.. ...|..|:.:.
  Fly   126 NRSSRPTSNNSNSNSNYSPNHDQ----LPAQLS-SRIINTRNGAISGVIVQLD-GRHLDPVEAYR 184

  Fly   186 GLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGS----ENMSRARHKHLSR 246
            |:|||..|.||.|||||.:...|.|:|.|....|||||:|||:  |..    |.|.:.|.::|.|
  Fly   185 GIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCPQRLPDI--HNETAALERMPKGRLEYLKR 247

  Fly   247 LLPYLRTESEDCLYLNLYVP-----------------------------HEEPQST--------- 273
            |||||:.:||||||||:|||                             .....||
  Fly   248 LLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGS 312

  Fly   274 PKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHN--IANYAL 336
            |.:|.|||::||||:|||||||||||||:|||:::|||:||||||||||..:.|.::  .|||.|
  Fly   313 PAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGL 377

  Fly   337 LDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVS-PVASG-LFHRAILMSGSAMSDW 399
            :|.||||||:||||.|||||.:.:||.||.||||||::|:.| .|..| ||:||||||||.::.|
  Fly   378 MDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPW 442

  Fly   400 AASNQSLQLTMQIAHALECPLN-EHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVD 463
            :..:...:....:||.:.|..: .|..      |:.|||.:....:|.:|....:|..:.||.:|
  Fly   443 SLVSNPAKYAAIVAHHVNCASDLPHAH------LMKCLREKTLDQLLSVPIRPPEFGFAFGPSID 501

  Fly   464 GHVI---------PNQPYK-----------------------------------VMGHYT--EHF 482
            |.||         |..|..                                   |:...|  ...
  Fly   502 GVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKL 566

  Fly   483 SRYDLLFGITESESYHTLAALALEEGLRENERDNLLRFYMQSRFDIRPDLALAATLKKYQDMYNN 547
            |||||:.|:|.:|::.:..:..::.|:..:.|..:|:.|:::.:....:...|..:.:|.| :..
  Fly   567 SRYDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTD-WER 630

  Fly   548 PIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEE 612
            |::.. :..||..|:.||||:||.|..||...|:..:|.:|:|||.:.:..|.:......|.||:
  Fly   631 PVQHP-INIRDETLEALSDAQVVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGED 694

  Fly   613 LAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHA--LEWDRY 675
            |.:||||||.......:.|||..|..|||.||.||:|||:||||....:    ..|.  .|..||
  Fly   695 LPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQME----TEHGSRQERSRY 755

  Fly   676 -DLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQEVITGH 739
             .::|..:....:.|||....|.:...||...::||...:||           |.|||.:.:
  Fly   756 KTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNLIPD-----------LHKPGGDNV--- 806

  Fly   740 MSKYGPRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFED 804
                 |..|                                             |::....|.::
  Fly   807 -----PAAH---------------------------------------------HQLHDDDDEDN 821

  Fly   805 LVTSTNSLESGEDHPQAPP--ETVAKSEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALP 867
            .:.|..|::     |..||  ...|.:.|.....|....:..:|||....:.|.|...|..
  Fly   822 NIPSDASVK-----PLNPPYISRAANAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYG---- 877

  Fly   868 FPAPKLGGTILSYDGANDEELKRCSKSRDGDDSFVLEMTRKSNTYEAIKTGQRSLSCSTVDTHTK 932
                  ||.|...|..:.:.....:.:....|.|....|..|.|.        ::.||.:..:..
  Fly   878 ------GGKIYPDDMMDGDHAGGAASASQDSDGFAAYSTALSVTI--------AIGCSLLILNVL 928

  Fly   933 VCEWMSSQEAPKSGSFNTATPPPQPIL---SDGRL--IICQDIEV------ADAALLIPQHMHEP 986
            :...:..|.    .....:.|.||..|   .:|::  .||.|:|.      :|.|.::..| |..
  Fly   929 IFAGVYYQR----DKTRLSEPRPQTKLKRQENGQMPNNICGDLETLTIHAKSDPATILSHH-HAM 988

  Fly   987 QHYEMLLQRQHSALTEPSD--EILQQQYPLRNHSHSHSDP 1024
            ||:::          .|.:  :|..:..|...|..|..||
  Fly   989 QHHQL----------PPPEFADIPHRAPPPPKHMKSLQDP 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	232/652 (36%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	89/186 (48%)
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	233/655 (36%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	64/96 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11301at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14500
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	P	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.820