DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	582	Identity:	149/582 - (25%)
Similarity:	245/582 - (42%)	Gaps:	143/582 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 YTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLP 218
            :|..:..|.|::.|:.|:  ..........|.|:|||:.|.|:.||..|..|.||||:.
  Fly    31 HTVILDTKYGQVRGLQRK--TVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVL------ 87

  Fly   219 PVCPQKLPDLSPHGSENMSRARHKHLSR-LLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVY 282
                            |.:..|.|.:.| :|..:...|||||:||:||   :...:.|...|:|:
  Fly    88 ----------------NCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYV---KALKSEKPLPVIVW 133

  Fly   283 LHGESFEWNSGNPYDGSVLSSY---GEVIVVTVNYRLGVLGFLR---PSIDAHNIANYALLDQIA 341
            ::|..|:  .|..........|   ..|:.|.:||||..||||.   |.:|..  .|..|.||:.
  Fly   134 IYGGGFQ--KGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVP--GNAGLKDQVM 194

  Fly   342 ALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAAS---N 403
            ||.||.:||..|.||.:.:||||.|.|:|.|:.:|.:....||||:||:.||.|:|:|..|   |
  Fly   195 ALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNN 259

  Fly   404 QSLQLTMQIAHALECPLNEHVEAEDDDVL----LDCLRHRRY--QDILHIPTALTQFSTSLGPIV 462
            .:.:|...:.:        ..:.:|.|||    ..|.|....  ||::::....:....:.||::
  Fly   260 WAFRLAQNLGY--------KGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVI 316

  Fly   463 DGH-----VIPNQ-------------PYKVMGHYTEHFSRYDLL----FGITESESYHTLAALAL 505
            :.:     |:|.:             |..|.|:..|....|.|:    :.:   :::|.:....:
  Fly   317 EPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWAL---KNFHNILPREV 378

  Fly   506 EEGLRENERDNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNL-EHRDVVLD----ILS 565
            .|......:|.|:|...|..|:        ..:::..:|:    :|.|: .||.:..|    ||:
  Fly   379 RETSSLEGQDLLVRRLKQLYFN--------NEMQESMEMF----EALNIFSHRQIWHDTHRFILA 431

  Fly   566 DARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPH-----------SIMG----EELAF 615
             .:...|...|           |:|.|..:|        ||           .|.|    :||::
  Fly   432 -RQSYAPKTPT-----------YLYRFDFDS--------PHFNQFRRLVCGDRIRGVAHADELSY 476

  Fly   616 IFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP------WKGIFINSHALE 671
            :|...:|:.....|..|...|::     :..||:|..:|||..|      |:.:.:..:|:|
  Fly   477 LFYNIIASKLDKSSMEYKTIERM-----VGMWTSFASSGNPNCPELGSAKWEAVQLKENAVE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	149/582 (26%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	56/153 (37%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	146/569 (26%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	39/110 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.900