DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	600	Identity:	168/600 - (28%)
Similarity:	246/600 - (41%)	Gaps:	136/600 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 FLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLL 248
            |..:|||:.|.|:.|||.|....||.       .|..|.:  |...|        .:..|.|:.|
  Fly    29 FERIPYAQPPVGHLRFMAPLPVEPWS-------QPLDCTK--PGQKP--------LQFNHYSKQL 76

  Fly   249 PYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSY---GEVIVV 310
            ..:    |||||||:|.   :...:|:...::|:..|..||  .|:|........|   .:|:||
  Fly    77 EGV----EDCLYLNVYA---KELDSPRPLPLIVFFFGGGFE--KGDPTKELHSPDYFMMRDVVVV 132

  Fly   311 TVNYRLGVLGFLRPSIDAHNI-ANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNY 374
            ||:||:|.||||..:..|..: .|..|.||:.|:.|||||.|.|.||...||..|.|.|||.|:|
  Fly   133 TVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHY 197

  Fly   375 LMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLN-EHVEAEDDDVLLDCLRH 438
            ||::|.|.||||:|||.||:.:..||     |.....:.|.|...|. |..|...|.::||.|:.
  Fly   198 LMLNPKAEGLFHKAILQSGNVLCSWA-----LCTIKNLPHRLAVNLGMESAEHVTDAMVLDFLQK 257

  Fly   439 RRYQDIL---------HIPTALTQFSTSLGPIVDGH-----VIPNQPY----KVMGHYTEHFSRY 485
            ...:.::         |:...:.||    ||:|:.:     .:||.|.    |..|      :|.
  Fly   258 LPGEKLVRPYLLSAEEHLDDCVFQF----GPMVEPYKTEHCALPNHPQELLDKAWG------NRI 312

  Fly   486 DLLFGITESESYHTLAALALEEGL---RENERDNLLRFYMQSRFDIRPDL--ALAATL-KKYQDM 544
            .:|...|..|.....|.:.:...|   .:.|.:::|      ..|::.:|  |||..| ::.|:.
  Fly   313 PVLMSGTSFEGLLMYARVQMAPYLLTSLKKEPEHML------PLDVKRNLPQALARHLGQRLQET 371

  Fly   545 Y---NNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADV---NRRNYMYVFGHNSATGPFAH 603
            :   |:| .|.:.|......:..|......|:|:|  ..:.|   :...|:|.|..:|.|  |.|
  Fly   372 HFGGNDP-SAMSPESLKAYCEYASYKVFWHPILKT--LRSRVKSSSASTYLYRFDFDSPT--FNH 431

  Fly   604 LPHSIMGEELAFI-------------FGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGN 655
            ......|::|..:             |...|....|         |.|..|.::...|:|.:|.|
  Fly   432 QRLKYCGDKLRGVAHVDDHSYLWYGDFSWKLDKHTP---------EFLTIERMIDMLTSFARTSN 487

  Fly   656 PKAPWKGIFINS---HALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDE 717
            |...    .|..   .|.||.      |..::.|...|||.             .|....||| |
  Fly   488 PNCK----LIQDQLPRAKEWK------PLNSKSALECLNIS-------------ENIKMMELP-E 528

  Fly   718 LNQIAAIQEQLQKPG 732
            |.::...:...|..|
  Fly   529 LQKLRVWESVCQSTG 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	161/576 (28%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	61/148 (41%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	164/584 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.900