DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Nrt

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	837	Identity:	198/837 - (23%)
Similarity:	291/837 - (34%)	Gaps:	281/837 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GVAAEKQPLHKGNELENAM--KLREAPKQSRVIGDITTTIQPDSDPGRSIGHQALRRAKAPPPSL 91
            |...:.:|...|:..|..:  |.:|..|.....||..|....|....|....:.||...|..||.
  Fly   123 GFFMKNKPKADGDGAEGELLEKEKEEDKDKEANGDAATGSGKDEQKSRPGLGERLRSFFARKPSA 187

  Fly    92 ELHFRQNLNKLFAGD-----ETTHVGHTNATDNTTA----------------------------- 122
            |...:|.:|    ||     |.| ...|.|.|.:.|
  Fly   188 EKEKKQLVN----GDADAKSEAT-AEATPAEDASDAPPKRGLLNAIKLPIANMIPKKKSNDDVEL 247

  Fly   123 ----AVLAT---------DEGSSEHEPSTTHHPE--------RRHVVPDKLQYTQEIQ------- 159
                |.||:         |:.:.:..|..|:..|        .:....:||...:|.|
  Fly   248 GLGKAGLASMETLDDSLKDQDTVDRAPVKTNGTEELKGELKDEKLAAEEKLAAEEEEQNRPVSLL 312

  Fly   160 ------------------------------------------VKQGR-LMGITRRFQVTSGLRQ- 180
                                                      :::|| :|.:|....| .|:::
  Fly   313 TRLRGYKCSVDDALIVFGILLFVLLLGVIGYVLTHETLTSPPLREGRYIMAVTGCGPV-EGVKED 376

  Fly   181 -VDQFLGLPYAEAPTGNRRFMP----PGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRAR 240
             ...|.|:|||:.|....|:.|    ....:.|.......:...||.|:|.:.:..|
  Fly   377 GAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVG-------- 433

  Fly   241 HKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSS-- 303
                          .||||||::..||.. .:.|  ..|:|.:..||.    ..|..|.:..|
  Fly   434 --------------DEDCLYLDVVTPHVR-YNNP--LPVVVLIGAESL----AGPSPGILRPSAR 477

  Fly   304 YG---EVIVVTVNYRLGVLGFLRPSID-----AH--NIANYALLDQIAALHWIKENIEAFGGDNS 358
            |.   :||.|..|:||||.|||  ::|     ||  ...||||.|.||.|:|||.||..||||..
  Fly   478 YSRSHDVIFVRPNFRLGVFGFL--ALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQ 540

  Fly   359 RVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEH 423
            .|||:||..||..|..|:.|....||:.||...||||:......::|.:...|:...|||
  Fly   541 SVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLEC----- 600

  Fly   424 VEAEDDDVLLDCLRHRRYQDI--------LHIPTAL--TQFSTSLGP-----IVDGHVIPNQPYK 473
              |:     :.|||....:.:        ||.|..|  .|.:.:.|.     ::||.|
  Fly   601 --AD-----IQCLREASSERLWAATPDTWLHFPVDLPQPQEANASGSRHEWLVLDGDV------- 651

  Fly   474 VMGHYTEHFSRYD------LLFGITESESYHTLAALALEEGLRE---NERDNLLRFYMQ-SRFDI 528
            |..|.::.:.|..      |:.|.|..|: ||       |.|||   |.....:|.|:: |:..
  Fly   652 VFEHPSDTWKREQANDKPVLVMGATAHEA-HT-------EKLRELHANWTREEVRAYLENSQIG- 707

  Fly   529 RPDLALAAT---LKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMY 590
                ||..|   ::||           |......::.|:||.|.|.|||        .|.|....
  Fly   708 ----ALGLTDEVIEKY-----------NASSYASLVSIISDIRSVCPLL--------TNARQQPS 749

  Fly   591 VFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGN 655
            |        ||..:......::||.:.....|..|.:..  :||:::....|:...:..:|..|.
  Fly   750 V--------PFYVVTQGEGPDQLATVDADVQAILGRYEP--HTVEQRRFVSAMQQLFYYYVSHGT 804

  Fly   656 PKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIG--IPPTVGYKYRQIYMNFW 710
            .::     |:.                |||.   :|:|  ..|...|    :..|:|
  Fly   805 VQS-----FVQ----------------NRRV---INVGQDAQPEEDY----LPCNYW 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	160/654 (24%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	61/156 (39%)
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	155/590 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810