DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Est-P

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	135/539 - (25%)
Similarity:	217/539 - (40%)	Gaps:	126/539 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 QVTSG-LRQVDQFL-----GLPYAEAPTGNRRFMPPGAPLP----WQGLKIARHLPPVCPQKLPD 227
            ::|:| :|..|..|     .:|.||.|||..||   .||.|    |..:..|...|..|.|
  Fly    28 EITNGKIRGKDNGLYYSYESIPNAEHPTGALRF---EAPQPYSHHWTDVFNATQSPVECMQ---- 85

  Fly   228 LSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNS 292
            .:...:||         ::|:     ..||||.:::|.|.:..:|:   :.|:|.|||.:|.:.|
  Fly    86 WNQFINEN---------NKLM-----GDEDCLTVSIYKPKKPNRSS---FPVVVLLHGGAFMFGS 133

  Fly   293 GNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDN 357
            |:.|....:...|.::||.:::.||.|||.... |.|...||.|.||..||.|||:||..|||..
  Fly   134 GSIYGHDSIMREGTLLVVKISFGLGPLGFASTG-DRHLPGNYGLKDQRLALQWIKKNIAHFGGMP 197

  Fly   358 SRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNE 422
            ..:.|:|||.|.|..:..::......|...||.:||:|:..|.......:...::...:.|. :.
  Fly   198 DNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCG-HT 261

  Fly   423 HVEAEDDDVLLDCLRHRRYQDILHIPTALTQFS----TSLGPIVDGHVIPNQ------------- 470
            :|.||    |.|||:.:...||:....:...||    ::.||:|:....|:.
  Fly   262 NVSAE----LKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSG 322

  Fly   471 -----PYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEEGLRENERDNLLRFYMQSRFDIRP 530
                 |:.|.  ||            ||...|:  ||..||......|  :.:.......||..|
  Fly   323 KFAQVPWAVT--YT------------TEDGGYN--AAQLLERNKLTGE--SWIDLLNDRWFDWAP 369

  Fly   531 DLALAATLKKYQDMYNNPIKATNLEHRDVVLDI----LSDARV-------VGPLLQTGMFH---- 580
            .|..      |:|     .|.|..:..|:..|:    |:|.|.       |..:....:|.
  Fly   370 YLLF------YRD-----AKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVP 423

  Fly   581 --ADVNRRN-----YMYVFGHNSATGPFAHLPH-------SIMGEELAFIFGAPLAAAGPFPSGN 631
              .|::|:.     |.:|:.:.:.:|....|.:       ::.|::...||.......|..|
  Fly   424 SAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRP--- 485

  Fly   632 YTVQEKLLSEAVMAYWTNF 650
               .|:::|:..:....:|
  Fly   486 ---DEEVISKKFIGMLEDF 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	135/539 (25%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	50/144 (35%)
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	135/539 (25%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	49/136 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.900