DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Gli

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	224/902 - (24%)
Similarity:	337/902 - (37%)	Gaps:	257/902 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 PDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKI 213
            ||...:.:.......|:||            :...|||:|||..||...||.||.....||.|:
  Fly   155 PDPKSFYRPYHSTVDRVMG------------ECSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQ- 206

  Fly   214 ARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYA 278
            |....|.|||.:              |:...::   .:....|||||||:|.| :......::|.
  Fly   207 AVDFGPACPQPV--------------RYTGATK---GIMDMDEDCLYLNVYSP-KTGAGVAQKYP 253

  Fly   279 VLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAAL 343
            |:||:||..|...:.|.:.|.:|:|:.:|:|||:|||||.||||... |.::..||.:|||..||
  Fly   254 VMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTG-DENSPGNYGILDQAMAL 317

  Fly   344 HWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWA-------A 401
            .|:.:|||.|.||.:.:||.|...|.|....|||:|....:..|.|..||||::|||       |
  Fly   318 RWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRA 382

  Fly   402 SNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRR--YQDILHIPTALTQFSTSL-----G 459
            .|.|..|    ...|.|.:      |....|::|||..|  |:      ....:||..:     |
  Fly   383 QNTSRVL----GQLLGCSI------ESSWKLVNCLRTGRSFYE------LGNAEFSPQVGSFPWG 431

  Fly   460 PIVD-GHVIP---------NQPYKVMGHYTE------HFSR----------YDLLFGITESES-- 496
            |::| ...:|         .:.::.:....|      .|:|          .:..|.:.::||
  Fly   432 PVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLS 496

  Fly   497 -YHTLAALALEEGLRENERDNLLRFYMQSRFDIRPDLALAATLKKY-----QDMYNNPIKATNLE 555
             |:.|.....::.:||    ::.|:    .:.:.|:....|.  ||     .|..||.|
  Fly   497 PYYELDGRFFDQKIRE----HVFRY----NYTLNPNGVYEAI--KYIYTFWPDPNNNTI------ 545

  Fly   556 HRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHL------PHSIMGEELA 614
            .||..:::|||.....|:.|......:.....||||.   :.|....:|      ||.|   |..
  Fly   546 IRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVL---NTTVEALNLPQWRKYPHDI---ERY 604

  Fly   615 FIFGAPLAAAGPFPS------GNYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWD 673
            |:.|||......||.      ..:|..::.:|...|..:|||.:.||| .|.:  .:..|
  Fly   605 FLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNP-TPQQ--VLGMH----- 661

  Fly   674 RYDLDWPEFNRRAQA---YLNIGIP--PTVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQ 733
                    |.|..|.   ||||...  .::...|||....||.:.||
  Fly   662 --------FQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLP------------------ 700

  Fly   734 EVITGHMSKYGPRDHGAEDPVRTLKLLLQEPSLA-----------------GPTQSGESTETAAE 781
            .||...:..|.|......:|...|::.....|:|                 ...||        :
  Fly   701 TVIGVLVPTYPPTTEYWWEPKEPLQIAFWSMSVACFFLIVLVVICCIMWRNAKRQS--------D 757

  Fly   782 NMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQAPPETVAKSEATMQLLIALITIIIVL 846
            ..|:                 ||:..:...||..:|       |.....|.|
  Fly   758 RFYD-----------------EDVFINGEGLEPEQD-------TRGVDNAHM------------- 785

  Fly   847 NLLIYGTFLLRQRRRRAKALPFPAPKLGGTILSYDGANDEELKRCSKSRDGDDSFVLEMTRKSNT 911
               :.....||.|....:....|:.|   |:.|....:...|:..|.         |.||:||::
  Fly   786 ---VTNHHALRSRDNIYEYRDSPSTK---TLASKAHTDTTSLRSPSS---------LAMTQKSSS 835

  Fly   912 YEAIKTGQRSLSCSTVDTH-TKVCEWMSSQEAPKSGSFNTATPPP-------QPILS 960
            ..::|:|   :|....:.| .|..|..::..:.::||......||       ||:.|
  Fly   836 QASLKSG---ISLKETNGHLVKQSERAATPRSQQNGSTAKVASPPVEEKRLLQPLSS 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	172/621 (28%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	62/151 (41%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	174/625 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920