Protein Alignment Nlg1 and Nlg2

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Alignment Length: 1251
• Identity: 326/1251 - (26%)
• Similarity: 486/1251 - (38%)
• Gaps: 373/1251 - (29%)

  Fly    73 GRSIGHQALRRAKAP--PPSLELHFRQNLNKLFAGD--ETTHVG-----HTNATDNTTAAVLAT- 127
            |.||..|.|..|.||  ..:.|.....:.:....||  ..|..|     |||......|.::||
  Fly    31 GASIAQQTLADADAPDEAKAKEREAETDADADAEGDAKAETETGKGTREHTNGDAEADARIMATG 95

  Fly   128 --------------DEGSSEHE--------------PSTTHHPERRH------------------ 146
                          :..:.||.              |:....|.|||
  Fly    96 ICIIRLITLKRFLENSKTEEHNQRRQQSATSAASAAPAGATSPRRRHLHYPGHSAVQPGHPEACA 160

  Fly   147 ---------VVPDKLQY----TQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRR 198
                     :.||..:.    :..::.|.|.|.||..|   :|.|  |:.|||:|||..|.|:.|
  Fly   161 LLVLLLLTSLWPDCCECLHGGSNTVKTKYGLLRGIVVR---SSPL--VEAFLGIPYASPPVGSLR 220

  Fly   199 FMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSE---NMSRARHKHLSRLLPYLRTESEDCLY 260
            ||||..|..|:.::.|....|||||.:| :.|:|.|   .:.|||...|.||||.|:.:||||||
  Fly   221 FMPPITPSTWKTVRSADRFSPVCPQNIP-IPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLY 284

  Fly   261 LNLYVPHE---------EPQSTPK-QYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYR 315
            ||:|||:|         :....|| :.:.:|::||||::||||||||||.|:::|.|||||:|:|
  Fly   285 LNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFR 349

  Fly   316 LGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPV 380
            ||:.|||:.........|:.|:|.:|.|||:|||:.|||||...:||:|:.|||...|.|:||||
  Fly   350 LGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPV 414

  Fly   381 ASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDIL 445
            ||.|..|.:|:||||:|.||.....|.:..::|....|    |.:...|| |..|||.:...::|
  Fly   415 ASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGC----HGDMLYDD-LAPCLRTKSVAELL 474

  Fly   446 HIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYT---------------EHFSRYDLLFGITESE 495
            .:.....:|.....|.|||.|| :.....:|..|               .:|.:.||:|.:|..|
  Fly   475 AVKVDHPRFLVGFAPFVDGTVI-SPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVE 538

  Fly   496 SYHTLAALALEEGLRENERDNLLRFYMQSRFDIRPDLALAATLKKYQD---MYNNPIKATNLEHR 557
            ||..|:|..||.|..|..||.:||.::::.|....:...|....:|.|   ...||     |..|
  Fly   539 SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNP-----LSSR 598

  Fly   558 DVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLA 622
            |..|..|||.....||::.|..|:....|.|...|.|.:....:.....|:.||::.|..|.|::
  Fly   599 DATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPMS 663

  Fly   623 AAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNP-KAPWKGIFIN-------------------- 666
            ...|.   |||.||:.:...::.|.:||.||||| ::..|.:..|
  Fly   664 PLFPH---NYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLT 725

  Fly   667 ------------------SHALEWDR---------------------------YDLD----WPEF 682
                              |:|:...|                           ||.|    |..:
  Fly   726 HPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAY 790

  Fly   683 NRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELP-------------------DELNQ----IAAI 724
            :...|.|:.:|....:...||...::.|...:|                   |::|.    ...:
  Fly   791 DVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVV 855

  Fly   725 QEQLQ-KPGQEVITGHMSKYGPRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYN--- 785
            :.||| ||.:                 :|.:    :::|......|....::..|.|....|
  Fly   856 RPQLQTKPAE-----------------DDNI----IIMQRSRTTTPPPPSKNPSTNATQALNPLG 899

  Fly   786 -APPTFGHVHKMQGGSDFEDLVTSTN---------SLESGEDHPQAPPETVAKSEATMQL----- 835
             ..||.... .:.|.....:|.|:.:         .:|:.:|...|....:...|...:|
  Fly   900 TGTPTTTEC-GIDGAMSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQF 963

  Fly   836 ------LIALITI---IIVLNLLIYGTFLLRQRRRRAKALPFPAPKLGGTILSYDGANDEELKRC 891
                  |||.:.:   :::||:||:.. :..||.:||:                |....|||:..
  Fly   964 QSYTTALIATVAVGCFLLILNVLIFAG-IYHQREKRAR----------------DAKTKEELQEG 1011

  Fly   892 SKSRD--------------------GD--DSFVL----------------------EMTRKSNTY 912
            ..|::                    ||  |::.|                      |.|::....
  Fly  1012 DNSKNSSILKLNALMGGGGACGSGPGDIADAYTLSGSVVDSKGGVGVVFGEYSCYDEKTKQLKEE 1076

  Fly   913 EAI-------KTGQRSL--------SCSTVD-------------THTKVCEWMSSQEA--PKSGS 947
            :.:       .|||.||        |.||:|             |::.:...|.|..|  .|.||
  Fly  1077 KLLVELPPSSSTGQTSLMIDNWGACSTSTLDLLKTKPGDPIEMVTYSALPSVMESTSAMSSKRGS 1141

  Fly   948 FNTAT----PPPQ---PILSDGRLIICQDIEVADAALL-----------IPQHMHEPQHYEMLLQ 994
            |...|    .|.|   .:.|..::.. :.||.|..|..           ||:....|:.:....|
  Fly  1142 FVDTTLQFNSPQQFDYAVQSSDQMSF-KAIEDAVKAAAGHDSEITRDDDIPEPPPPPRSFLAAQQ 1205

  Fly   995 RQHSALTEPSDEILQQ 1010
            :|.....:....||:|
  Fly  1206 QQQQQQQQQQTGILRQ 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	218/653 (33%)
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	206/566 (36%)