DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg1 and CG5397

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	130/511 - (25%)
Similarity:	214/511 - (41%)	Gaps:	94/511 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 FLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLL 248
            |||:.|||.|.|..|:..|............:|.|| |      :.||..              .
  Fly    76 FLGMHYAEPPVGPLRYSRPVYKRLAGDFNATKHGPP-C------IQPHPQ--------------F 119

  Fly   249 PYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVN 313
            |......||||.||:|.|....::|  ...|.|::|...:.:.|...||.:.::..| .|||...
  Fly   120 PQRIIGDEDCLLLNVYTPQMPDETT--GLPVFVWIHPGGYRYGSAAQYDATPMAQRG-AIVVAPQ 181

  Fly   314 YRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVS 378
            ||||.||.:.......: .|.|:.|..|||.|:.:.|..|||:..:|..:||.:|||...||.:|
  Fly   182 YRLGSLGIMGDGTKQFD-GNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMS 245

  Fly   379 PV--ASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRY 441
            |.  ::|..|..:.|||:|:|.:|...:.:|...::|....||....:|      :::|||.:..
  Fly   246 PTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELE------IVNCLRSKSA 304

  Fly   442 QDIL----HIPT------ALTQ-------FSTSLGPIVDGHVIPN----QPYKVMGHYTEHFSRY 485
            :||:    .:.|      ||.:       |...:....||..:|:    :|.:.:  .:.:||..
  Fly   305 EDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQL--KSSNFSGI 367

  Fly   486 DLLFGITESESYHTLAALALEEGLRENER------DNLLRFYMQSRFD------IRPDL-----A 533
            .||.|:|:.|:.:::....:|:.....|:      |:|.:.....:.|      .:|:|     .
  Fly   368 PLLTGVTKHETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSV 432

  Fly   534 LAATLKKYQDMYNNPIKATNLEH-RDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSA 597
            |..||   ||::..| :|.|::. ...|::..:|.....|.:.|....:.: ...:||.|.:|..
  Fly   433 LTPTL---QDVWKVP-QALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRL-APAFMYSFEYNGT 492

  Fly   598 -------------TGPFAH-LPHSI-MGEELAFIFGAPLAAAGPFPSGNYTVQEKL 638
                         ....|| .|.:: .|:|:.::|.|......|......|..|.|
  Fly   493 KSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPMEETRLTSAEDL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	130/511 (25%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	48/146 (33%)
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	130/511 (25%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	61/203 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.900