DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg1 and cel.1

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_955901.2	Gene:	cel.1 / 322481	ZFINID:	ZDB-GENE-030131-1201	Length:	550	Species:	Danio rerio

Alignment Length:	562	Identity:	158/562 - (28%)
Similarity:	252/562 - (44%)	Gaps:	106/562 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 GRLMGITRRFQVTSGL-RQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLP 226
            |.:.|.:|    :.|| |.:|.|.|:|:|..|   :||..|.|...|:|:.........|.|
Zfish    30 GMVQGKSR----SVGLFRYMDTFKGIPFAAPP---KRFEKPVAHPGWEGVLKTTDYRKRCLQ--- 84

  Fly   227 DLSPHGSENMSRARHKHLSRLLPYLRTE---SEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESF 288
                                 |..|.|:   ||||||||::||  :.::......|:|:::|.:|
Zfish    85 ---------------------LNLLATDVIGSEDCLYLNIWVP--QGRTVSSNLPVMVFIYGGAF 126

  Fly   289 EWNSGNP--------YDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHW 345
            ....|..        |||..::..|.|||||.|||:|.|||:....|... .||.|.||.||:.|
Zfish   127 LLGGGQGANFLDNYLYDGEEMADRGNVIVVTFNYRVGALGFMSTGDDGIP-GNYGLWDQHAAISW 190

  Fly   346 IKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTM 410
            :..||:||||:...:||.|.|.|||.||:.:::|...|:..|||..||.|:..||.|....|...
Zfish   191 VHRNIKAFGGNPDNITLFGESAGAASVNFQIITPKNKGMIRRAISQSGVALCPWAISRNPRQFAE 255

  Fly   411 QIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALT-----QFSTS----------LGP 460
            :||..:.||:        |..:.|||:...       |.|:|     :.::|          |.|
Zfish   256 EIATKVGCPI--------DSGMADCLKRAD-------PKAVTLAGKLKLTSSPDAPIVHNLYLSP 305

  Fly   461 IVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAAL---ALEEGLRENERDNLLRFYM 522
            ::||..||::|..:.|:..:    .|.:.|:.:.:: |..|.:   ::...|.....:.:.....
Zfish   306 VIDGDFIPDEPETLFGNAAD----IDYIAGVNDMDA-HIFATIDIPSINNALTTTPVEEVQALAT 365

  Fly   523 QSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHAD--VNR 585
            ....|...|..: ||.::|...:.:  |....:.:..|:::.:|...:.|.......|.|  .:.
Zfish   366 ALSRDRGQDAGI-ATFQEYTVNWGD--KPNKEKVKQTVVELETDYMFLVPTQAALYLHTDNAKSA 427

  Fly   586 RNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNF 650
            |.:.|:|..:|....|.....:...:||.::||.|.|.    |.| |..:.:.:|:.::|||:||
Zfish   428 RTFSYLFTESSRIPVFPLWMGADHADELQYVFGKPFAT----PLG-YFPRHRDVSKYMIAYWSNF 487

  Fly   651 VKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNI 692
            .:||:|.   ||         ..:..:.||||:.....||:|
Zfish   488 AQTGDPN---KG---------ESKVPVTWPEFSNPGHQYLDI 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	158/562 (28%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	58/152 (38%)
cel.1	NP_955901.2	COesterase	25..517	CDD:306613	157/560 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910