Protein Alignment Nlg1 and CES4A

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 196/651 - (30%)
• Similarity: 297/651 - (45%)
• Gaps: 140/651 - (21%)

  Fly   141 HPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAP 205
            |.:|..||           .|.|.|.|    .|:..|...:..|||:|::..|.|..||.||..|
Human    46 HTKRPQVV-----------TKYGTLQG----KQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPP 95

  Fly   206 LPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRAR------HKHLSRLLP--------------- 249
            .||:|::.|...||.....   ||| |...::|:|      .:..:.|||
Human    96 EPWKGIRDATTYPPGWSLA---LSP-GWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESW 156

  Fly   250 ------YLRTE--------SEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSV 300
                  |:.|.        ||||||||:|.|...|..  .|..|:|:..|.:|...:.:.|:||.
Human   157 GQLASMYVSTRERYKWLRFSEDCLYLNVYAPARAPGD--PQLPVMVWFPGGAFIVGAASSYEGSD 219

  Fly   301 LSSYGEVIVVTVNYRLGVLGFLR---PSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTL 362
            |::..:|::|.:.:|||:.||||   .:.|:|...|:.||||:|||.|::|||.|||||...|||
Human   220 LAAREKVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTL 284

  Fly   363 MGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAE 427
            .|.|.||..::.||:||:|||||||||..||:|:.....::..|::..::||...|..|
Human   285 FGQSAGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITSNPLKVAKKVAHLAGCNHN------ 343

  Fly   428 DDDVLLDCLRHRRYQDILHIPTAL-----------TQFSTSLGPIVDGHVIPNQPYKVMGHYTE- 480
            ...:|::|||......::.:...:           .:...|:.|:|||.|||:.|..::   |:
Human   344 STQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPVVDGVVIPDDPLVLL---TQG 405

  Fly   481 HFSRYDLLFGITESESYHTLAALALEEGLREN--ERDNLLRFYMQSR--FDIRPDLALAATLKKY 541
            ..|....|.|:...| ::.|....::..|...  .::.:.:....:|  .:|..: .:...:::|
Human   406 KVSSVPYLLGVNNLE-FNWLLPYIMKFPLNRQAMRKETITKMLWSTRTLLNITKE-QVPLVVEEY 468

  Fly   542 QDMYNNPIKATNLEH-----RDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNS----- 596
            .|..|        ||     |:.::||:.||..|...|||..:|.|.....|:|.|.|::
Human   469 LDNVN--------EHDWKMLRNRMMDIVQDATFVYATLQTAHYHRDAGLPVYLYEFEHHARGIIV 525

  Fly   597 --ATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP 659
              .|....|      |:|:.|:||      |||.:|....:||.||..:|.||.||.:||||
Human   526 KPRTDGADH------GDEMYFLFG------GPFATGLSMGKEKALSLQMMKYWANFARTGNP--- 575

  Fly   660 WKGIFINSHALE-WDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFW----NKELPDELN 719
                  |...|. |.||:.|        :.||.:.....||.|.::..|.||    ..:.|::..
Human   576 ------NDGNLPCWPRYNKD--------EKYLQLDFTTRVGMKLKEKKMAFWMSLYQSQRPEKQR 626

  Fly   720 Q 720
            |
Human   627 Q 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	188/619 (30%)
CES4A	XP_011521323.1	COesterase	50..613	CDD:395084	190/631 (30%)