DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and cest-9.2

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_741910.3	Gene:	cest-9.2 / 259729	WormBaseID:	WBGene00007695	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	770	Identity:	175/770 - (22%)
Similarity:	276/770 - (35%)	Gaps:	222/770 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 PDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKI 213
            || :|..:.|:...||:.|||   :.:........|..:|:|:.|.|..||.||..|..|.|:..
Worm    16 PD-IQSLKVIETSYGRVRGIT---EWSDDNNHKYMFKSVPFAKPPIGKLRFAPPQYPDSWSGVLD 76

  Fly   214 ARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYA 278
            |....|.|      ||   :.:.:....:|:          ||||||:|::...:..:|   :.|
Worm    77 ASKYSPAC------LS---NSSTTSTPQEHV----------SEDCLYINIFTSEKCLRS---KCA 119

  Fly   279 VLVYLHGESFEWNSGNPY-DGSVLSSY--GEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQI 340
            |:||.||.::..:|...: |..:|..|  .:||:.....||||.|.|.....|....|..:.|.:
Worm   120 VIVYFHGGAYNGDSATMFPDNFILERYVAEDVILAIPGVRLGVFGQLYFGPSALLTENLFMFDAV 184

  Fly   341 AALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYL----MVSPVASGLFHRAILMSGSAM---SD 398
            .||.::...|..||||..:||:||||:|...|..|    .|.|... ||.:.|::||:.|   .|
Worm   185 QALDFVHNEIPNFGGDPKQVTIMGHSSGGTLVEALGFSNSVDPDLK-LFQQIIVLSGTGMFGFYD 248

  Fly   399 WAASNQSLQLTMQIAHALECPLNEHVEAEDDDV--LLDCLRHRRYQDILHIPTALTQFSTSLGPI 461
            ....|..:     |:..|.|......|..|.::  :|:|:|.
Worm   249 LLVDNSFI-----ISEKLGCFNGTQEERTDANIAEILECMRQ----------------------- 285

  Fly   462 VDGH-------------------VIPNQPYKVMGHYTEHF----SRYDLLFGITESESYHTLAAL 503
            :|||                   ::...|:..:....|.|    |..:.:||.||.|.
Worm   286 IDGHEIVGMQKHMEDVYKLTFKSLLRGAPFMELNGKIEKFRNSTSPRNAIFGTTEYEF------- 343

  Fly   504 ALEEGLRENERDNLLRFYMQSRF-DIRPDLALA-----ATLKKYQDMYNNPIKATNLEHRDVVLD 562
                   .||.:..|  |:.:.| |....:|:|     ..::....|.|.          |.|..
Worm   344 -------RNEVERYL--YITTTFLDFENPVAVAQHFDDELMQNMDTMING----------DAVSI 389

  Fly   563 ILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPF 627
            .:|.|.....:...|   |||      |:|       .....|:|....::.:..|......
Worm   390 FVSAAAFSSAMANAG---ADV------YLF-------ETRQWPYSFHVSDMQYFIGIHREVL--- 435

  Fly   628 PSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNI 692
                :|....:|.........||.|||.|...|       ::||.::.:            ||.:
Worm   436 ----HTHDMDILDSFYSKLLVNFTKTGAPSPEW-------NSLEPEKMN------------YLEL 477

  Fly   693 ------GIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQEVITGHMSKYGPRDH-GA 750
                  |..|.:...|....::||..::.|....|..:::              ||..||:: |.
Worm   478 RVDTRNGKGPVMLEGYHDKEVSFWYGDMMDYDRNITKMRQ--------------SKGLPRENQGV 528

  Fly   751 EDPVRTLKLLLQEPSLA---GPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSL 812
            |..::....:::..:.|   ..||...||.|..                        |.|||...
Worm   529 ESQLKYWSSIVEPRTTAHANNATQENISTSTNV------------------------LFTSTAQY 569

  Fly   813 ESGEDHPQAPPETVAKSEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALP 867
            .|.|.....|    ...:....|:|||:.:|.||      .|:..::.||.:.:|
Worm   570 ISREFKNSTP----ILQQWWFYLIIALVVMIFVL------IFISLRKPRREEEVP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	139/603 (23%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	48/154 (31%)
cest-9.2	NP_741910.3	Abhydrolase	19..501	CDD:304388	139/603 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810