DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	168/563 - (29%)
Similarity:	266/563 - (47%)	Gaps:	79/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 VDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLS 245
            :..|||:|:|:.|.|..||.||..|.||.|::.|...|.:|.|         ::.|:....|.:
  Rat    55 IHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQ---------TDIMNLDGIKEM- 109

  Fly   246 RLLPYLRTESEDCLYLNLYVP-H-EEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVI 308
            :|..:....||||||||:|.| | .|..:.|    |:|::||......|.:..|.|.|::..|::
  Rat   110 KLTVHPTPMSEDCLYLNIYTPAHAREGSNLP----VMVWIHGGGLVLGSASMNDASTLAATEEIV 170

  Fly   309 VVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVN 373
            :|::.||||||||.... |.:...|:..|||:|||.|:::||..|||::.:||:.|.|.|...|:
  Rat   171 IVSIQYRLGVLGFFSTG-DQNARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVS 234

  Fly   374 YLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRH 438
            ..:|||::.||||.||:.||.|:.....|::|..:...:|:...|      ||.|.:.|:.|||.
  Rat   235 SHVVSPMSKGLFHGAIMQSGVALLPDLISDKSEVVYKTVANLSGC------EAPDSEALIRCLRA 293

  Fly   439 RRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESE-SYHTLAA 502
            :..|:||    |:.|....:..:|||..:|..|.:::.  :..|.....:.||...| .:.....
  Rat   294 KSKQEIL----AINQVFKMIPGVVDGKFLPKHPQELLA--SGDFHPVPSIIGINTDECGWGIPVF 352

  Fly   503 LALEEGLRENERDNLLRFYMQSRFDIR-PDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSD 566
            |.|:..:::..|:.|......:...:. |...:...:::|.....||   ..|:.:  ...:|.|
  Rat   353 LGLDHIIKKITRETLPTVLKSTAAQMMLPPECIDLIMEEYMGDTENP---ETLQEQ--FRHMLGD 412

  Fly   567 ARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIM-----------GEELAFIFGAP 620
            ...|.|.||...|     :|:...|:.:.     |.|||..|.           |:::.|:||:.
  Rat   413 FMFVIPALQVAHF-----QRSQAPVYFYE-----FQHLPSFIKQVRPSHVKADHGDDILFVFGSY 467

  Fly   621 LAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDL-DWPEFNR 684
            |...    :.:.|.:|:||...||.||.||.:||||...                || .||..:.
  Rat   468 LWGM----TFDLTEEEELLKRRVMKYWANFARTGNPNGE----------------DLPHWPVLDH 512

  Fly   685 RAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQ 727
            ..| ||.:...|.||...:...:.||.|.||.::.::...|.:
  Rat   513 DEQ-YLQLNTQPAVGRALKARRLQFWTKTLPQKIQELKGSQSK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	162/544 (30%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	57/146 (39%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	162/544 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910