DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	774	Identity:	245/774 - (31%)
Similarity:	370/774 - (47%)	Gaps:	127/774 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 GRLMGITRRFQVTSG-LRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLP 226
            |:|.|  .|..:.|. |..|||:||:|||..|.|.:||:||..|..|.|::.|.|.||||||.:.
Mouse    46 GKLRG--ARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIH 108

  Fly   227 DLSPHGSENMSRARH-KHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQ-------------- 276
            ...|   |.|..... .:|..:..|::..:|||||||:|||.|:.....||
Mouse   109 TAVP---EVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDED 170

  Fly   277 ------YAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYA 335
                  ..|:||:||.|:...:||..|||||:|||.|||:|:|||:||||||.....|.. .||.
Mouse   171 IRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQAAK-GNYG 234

  Fly   336 LLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWA 400
            |||||.||.|:.|||..||||..|:|:.|...||:||:.|.:|..:.|||.|||:.||||:|.||
Mouse   235 LLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWA 299

  Fly   401 ASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGH 465
            .:.|.::.|..:|..:.|.:.:.|:      ::||||.:..::::.......::..:.||::||.
Mouse   300 VNYQPVKYTSLLADKVGCNVLDTVD------MVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGD 358

  Fly   466 VIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA-LEEGLR--------ENERDNLLRFY 521
            |||:.|..:|..  ..|..||::.|:.:.|....:..:. .|:|:.        .|..|||.. |
Mouse   359 VIPDDPEILMEQ--GEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYG-Y 420

  Fly   522 MQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILSDARVVGPLLQTGMFHADVNR 585
            .:.:..:|..:..         ||.:.....|.| .|..::.:.:|.:.|.|.:.|...||....
Mouse   421 PEGKDTLRETIKF---------MYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGS 476

  Fly   586 RNYMYVFGHN------SATGPFAHLPHSIMGEELAFIFGAPLAAAGP---FPSGNYTVQEKLLSE 641
            ..|.|.|.|:      .|....||      |:|:.::||.|:  .||   ||. |::..:.:||.
Mouse   477 PTYFYAFYHHCQSLMKPAWSDAAH------GDEVPYVFGVPM--VGPTDLFPC-NFSKNDVMLSA 532

  Fly   642 AVMAYWTNFVKTGNPK--APWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQ 704
            .||.|||||.|||:|.  .|....||::.|..::  ::.|.::|.|.|.||:||:.|.|...||.
Mouse   533 VVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFE--EVAWSKYNPRDQLYLHIGLKPRVRDHYRA 595

  Fly   705 IYMNFWNKELPDELN-----QIAAIQEQLQKPGQEVITGHMSKYGPRDHGAEDPVRTLKLLLQEP 764
            ..:.||...:|...|     ...:...::..|.    |.|.|....|.:|     :|..  .:.|
Mouse   596 TKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPD----TTHSSHITRRPNG-----KTWS--TKRP 649

  Fly   765 SLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQAPPETVAKS 829
            ::: |..|.|          |||.::      .|..|...|:     :|:..|:
Mouse   650 AIS-PAYSNE----------NAPGSW------NGDQDAGPLL-----VENPRDY----------- 681

  Fly   830 EATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPAPKLGGTILSYDGANDEEL 888
            ...:.:.||:...::.||:|.:.....|:.:||.:.|..|:|:.|........|.:|||
Mouse   682 STELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGTAPEEEL 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	206/589 (35%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	76/164 (46%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	206/589 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668		15/73 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780