DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	597	Identity:	178/597 - (29%)
Similarity:	276/597 - (46%)	Gaps:	102/597 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 HPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQ-VDQFLGLPYAEAPTGNRRFMPPGA 204
            ||....||          ...:|:::|   ::....|..| |..|||:|:|:.|.|:.||.||..
  Rat    21 HPSSPPVV----------DTTKGKVLG---KYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPEP 72

  Fly   205 PLPWQGLKIARHLPPVCPQK------LPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNL 263
            ..||..:|.....||:|.|.      |.|:...|.||:.          |.:    ||||||||:
  Rat    73 AEPWSFVKNTTTYPPMCSQDGVVGKLLADMLSTGKENIP----------LEF----SEDCLYLNI 123

  Fly   264 YVPHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDA 328
            |.|.:..:::  :..|:|::||........:||.|..||::..|:|||:.||||:.|..... |.
  Rat   124 YSPADLTKNS--RLPVMVWIHGGGLIIGGASPYSGLALSAHENVVVVTIQYRLGIWGLFSTG-DE 185

  Fly   329 HNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSG 393
            |:..|:|.|||:|||.|:::||..|||:...||:.|.|.|...|:.|::||:|..||||||..||
  Rat   186 HSRGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESG 250

  Fly   394 SAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSL 458
            ..::.......:..:...||....|  |....|    .::.|||.:...::|.:...|.  :||:
  Rat   251 VVLTTNLDKKNTQAVAQMIATLSGC--NNTSSA----AMVQCLRQKTEAELLELTVKLD--NTSM 307

  Fly   459 GPIVDGHVIPNQPYKVMGHYTE-HFSRYDLLFGITESE---SYHTLAALALEEGLRENER--DNL 517
            ..::||.|:|..|.:::   || .|:....:.|..:.|   ...|:....|.|| |.||:  .:|
  Rat   308 STVIDGVVLPKTPEEIL---TEKSFNTVPYIVGFNKQEFGWIIPTMMGNLLSEG-RMNEKMASSL 368

  Fly   518 LRFYMQSRFDIRPDL-----ALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTG 577
            ||     ||.  |:|     .:.|.::||....::|.|     .::::||:.||.....|.:...
  Rat   369 LR-----RFS--PNLNISESVIPAIIEKYLRGTDDPAK-----KKELLLDMFSDVFFGIPAVLMS 421

  Fly   578 MFHADVNRRNYMYVFGHNSATGPFA--HLPHSIM---GEELAFIFGAPLAAAGPFPSGNYTVQEK 637
            ....|.....|||.|.:..:   |.  ..|.::.   |:|:..:||.|....|.      :.:|.
  Rat   422 RSLRDAGAPTYMYEFQYRPS---FVSDQRPQTVQGDHGDEIFSVFGTPFLKEGA------SEEET 477

  Fly   638 LLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKY 702
            .||:.||.:|.||.:.|||         |...|.      .|||:::: :.||.||.......|.
  Rat   478 NLSKLVMKFWANFARNGNP---------NGEGLP------HWPEYDQK-EGYLQIGATTQQAQKL 526

  Fly   703 RQIYMNFWNKEL 714
            :...:.||.:.|
  Rat   527 KGEEVAFWTELL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	171/579 (30%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	54/144 (38%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	173/588 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810