Protein Alignment Nlg1 and CES3

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 187/611 - (30%)
• Similarity: 301/611 - (49%)
• Gaps: 76/611 - (12%)

  Fly   136 PSTTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFM 200
            |:|...||...         .|:....||:.|  |:..|....|.|:.|||:|:|:.|.|..||.
Human    23 PATATGPEVAQ---------PEVDTTLGRVRG--RQVGVKGTDRLVNVFLGIPFAQPPLGPDRFS 76

  Fly   201 PPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYV 265
            .|....||:|::.|...||:|.|.:        |:|:.:|.....:  ..:.:.|||||.||:|.
Human    77 APHPAQPWEGVRDASTAPPMCLQDV--------ESMNSSRFVLNGK--QQIFSVSEDCLVLNVYS 131

  Fly   266 PHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHN 330
            |.|.|..:.:  .|:|::||.:....:...||||.|::||:|:||||.||||||||.... |.|.
Human   132 PAEVPAGSGR--PVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTG-DEHA 193

  Fly   331 IANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSA 395
            ..|...||.:|||.|::|||..||||.:.||:.|.|.|.:.::.|::||||:|||||||..||..
Human   194 PGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVI 258

  Fly   396 MSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGP 460
            .:.....:....|..:||:.|.|..:...|      ::.||:.:..::::    ...:...::.|
Human   259 TTPGIIDSHPWPLAQKIANTLACSSSSPAE------MVQCLQQKEGEELV----LSKKLKNTIYP 313

  Fly   461 I-VDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESE-SYHTLAALALEEGLRENERDNLLRFY-- 521
            : |||.|.|..|.:::..  :.|.....|.|:...| |:.......|.:.:.:..|:::|...
Human   314 LTVDGTVFPKSPKELLKE--KPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTP 376

  Fly   522 MQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRR 586
            :.:..|:.|:: :...:.:|... |:..:|.....::.:.|:..:.    |.:....:..|....
Human   377 VLTSLDVPPEM-MPTVIDEYLGS-NSDAQAKCQAFQEFMGDVFINV----PTVSFSRYLRDSGSP 435

  Fly   587 NYMYVFGHNSATGPFAHLPHSIM----GEELAFIFGAPL----AAAGPFPSGNYTVQEKLLSEAV 643
            .:.|.|.|..::  ||.:..:.:    |.|.||:||.|.    ::...||..  |.:||.||..:
Human   436 VFFYEFQHRPSS--FAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEA--TEEEKQLSLTM 496

  Fly   644 MAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMN 708
            ||.||:|.:||:|         ||.||.      .||:|| :|:.||.|...|..|.|:|:.:|.
Human   497 MAQWTHFARTGDP---------NSKALP------PWPQFN-QAEQYLEINPVPRAGQKFREAWMQ 545

  Fly   709 FWNKELPDELNQIAAIQEQLQKPGQE 734
            ||::.||.::.|..  |:|..:..||
Human   546 FWSETLPSKIQQWH--QKQKNRKAQE 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	174/564 (31%)
CES3	NP_079198.2	COesterase	32..547	CDD:395084	174/576 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571		2/2 (100%)