Protein Alignment Nlg1 and Ces4a

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_666325.2
• Gene: Ces4a / 234677
• MGIID: 2384581
• Length: 563
• Species: Mus musculus
• Alignment Length: 599
• Identity: 187/599 - (31%)
• Similarity: 276/599 - (46%)
• Gaps: 110/599 - (18%)

  Fly   167 GITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPH 231
            ||.:..||..|...:..|||:|:::.|.|.|||.||..||||.|::.|...||.|.|
Mouse    41 GILQGKQVHVGDTPIQVFLGIPFSKPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQ-------- 97

  Fly   232 GSENMSRARHKHLSRLLPYLRTE--------SEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESF 288
              |:..:.       |..||.|.        ||||||||:|.|...|.:  ....|:|:..|.:|
Mouse    98 --ESWGQI-------LSMYLNTRKQYKWLHFSEDCLYLNVYAPVLAPGA--PLLPVMVWFPGGAF 151

  Fly   289 EWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAF 353
            ...|.:.|:||.|::.|:|::|.:.||||:|||.... ::|...|:.||||||||.|::||||||
Mouse   152 LAGSASTYEGSELAARGKVVLVFLQYRLGILGFFSTG-NSHARGNWGLLDQIAALRWVQENIEAF 215

  Fly   354 GGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALEC 418
            |||...|||.|.|.||..|:.|||||:|.||||:||..||:|:.....:...|....:|||...|
Mouse   216 GGDPDSVTLFGQSAGAMSVSGLMVSPLAQGLFHQAISQSGTAVLKAFITPDPLTSAKKIAHLAGC 280

  Fly   419 PLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTS-----------LGPIVDGHVIPNQPY 472
            ..|      ...|:::|||....:::..:...::.|..:           |.|:|||.|.|..|.
Mouse   281 DHN------STKVMVECLRSLSAEEVTLVSKRMSFFQANSHKDPKEIVWFLSPVVDGVVFPEDPV 339

  Fly   473 KVMGHYTEHFSRYDLLFGITESE---SYHTLAALALEEGLRENERDNLLRFYMQSRFDIRPDLAL 534
            .::..  ........|.|:..:|   :...|..:.|.:.:......|.:.:......:|..:...
Mouse   340 VLLTR--GQVKPVPYLLGVNNAEFEWNLPFLMKIQLNQRMMNQTNINKILWSFNVLLNITKEQVP 402

  Fly   535 AATLKKYQDMYNNPIKATNLEH-----RDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGH 594
            ....:...|..:|        |     |:.::|::.||..|...||...:|.|.....|:|.|.|
Mouse   403 VVAREYLNDAISN--------HDWKMFRNRLIDLIGDATFVYATLQAARYHRDAGSPVYLYEFKH 459

  Fly   595 NSATG----PFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGN 655
            ::::|    |:....|   |:||:::||:      ||..|:...:||..|..:|.||.||..|||
Mouse   460 HASSGIIIKPYNGADH---GDELSYLFGS------PFSKGSSAGEEKEFSLQMMKYWANFAHTGN 515

  Fly   656 P---KAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDE 717
            |   |.|:           |.|:|.|        :.||.:.....||.|.::..|.||::
Mouse   516 PNGEKLPY-----------WPRFDKD--------EKYLQLDFDTRVGVKLKEKKMAFWSQ----- 556

  Fly   718 LNQIAAIQEQLQKP 731
                   ..|.|||
Mouse   557 -------LRQSQKP 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	181/576 (31%)
Ces4a	NP_666325.2	COesterase	33..554	CDD:395084	181/576 (31%)