Protein Alignment Nlg1 and Ces2c

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_663578.1
• Gene: Ces2c / 234671
• MGIID: 2385905
• Length: 561
• Species: Mus musculus
• Alignment Length: 597
• Identity: 182/597 - (30%)
• Similarity: 276/597 - (46%)
• Gaps: 91/597 - (15%)

  Fly   149 PDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKI 213
            |.:..:|.:|   ||.|:.:.   ...:|   |..|||:|:|:.|.|..||.||.||.||.|::.
Mouse    34 PIRNTHTGQI---QGSLIHVK---DTKAG---VHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRD 89

  Fly   214 ARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVP-H-EEPQSTPKQ 276
            ....|.:|.|.|..|:..|..:|     |.:....|.    ||||||||:|.| | .|..:.|
Mouse    90 GTAHPAMCLQNLDMLNEAGLPDM-----KMMLSSFPM----SEDCLYLNIYTPAHAHEGSNLP-- 143

  Fly   277 YAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIA 341
              |:|::||.:......:.:|||:|:...:::|||:.||||||||.... |.|...|:..|||.|
Mouse   144 --VMVWIHGGALVIGMASMFDGSLLTVNEDLVVVTIQYRLGVLGFFSTG-DQHARGNWGYLDQAA 205

  Fly   342 ALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSL 406
            ||.|:::||..|||:..|||:.|.|.|...|:..:|||::.||||.||:.||.|:.....|..|.
Mouse   206 ALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVALLPDLISETSE 270

  Fly   407 QLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQP 471
            .::..:|....|      ||.|...|:.|||.:...:||    |:.:....:..:|||...|..|
Mouse   271 MVSTTVAKLSGC------EAMDSQALVRCLRGKSEAEIL----AINKVFKMIPAVVDGEFFPRHP 325

  Fly   472 YKVMGHYTEHFSRYDLLFGITESE-SYHTLAALALEEGLRENERDNLLRFYMQSRFDIR-----P 530
            .:::.  :|.|.....:.|:...| .:.....:...:.::...|:||......:...:.     .
Mouse   326 KELLA--SEDFHPVPSIIGVNNDEFGWSIPVVMGSAQMIKGITRENLQAVLKDTAVQMMLPPECS 388

  Fly   531 DLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMF---HADVNRRNYMYVF 592
            ||.:...:...:|.....|:.|         :::.|...|.|.||...|   ||.|    |.|.|
Mouse   389 DLLMEEYMGDTEDAQTLQIQFT---------EMMGDFMFVIPALQVAHFQRSHAPV----YFYEF 440

  Fly   593 GHNSATGPFAHLPH--SIMGEELAFIF-----GAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNF 650
            .|..:.......||  :...:|:.|:|     |..|         ::|.:|:|||..:|.||.||
Mouse   441 QHPPSYFKDVRPPHVKADHADEIPFVFASFFWGMKL---------DFTEEEELLSRRMMKYWANF 496

  Fly   651 VKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELP 715
            .:.|||         ||..|.:      ||..:...| ||.:.|.|.||...:...:.||.|.||
Mouse   497 ARHGNP---------NSEGLPY------WPVMDHDEQ-YLQLDIQPAVGRALKAGRLQFWTKTLP 545

  Fly   716 DELNQIAAIQEQ 727
            .::.::.|.|::
Mouse   546 QKIQELKASQDK 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	174/574 (30%)
		Aes	<263..>408	CDD:223730	60/146 (41%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	175/578 (30%)
		Aes	<130..>233	CDD:223730	44/107 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561		182/597 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810