Protein Alignment Nlg1 and Ces1f

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_659179.1
• Gene: Ces1f / 234564
• MGIID: 2142687
• Length: 561
• Species: Mus musculus
• Alignment Length: 583
• Identity: 163/583 - (27%)
• Similarity: 274/583 - (46%)
• Gaps: 85/583 - (14%)

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222
            :....|:::|  :...|....:.|..|||:|:|:.|.|:.||.||....||..:|.|...||:|.
Mouse    26 VDTAHGKVLG--KHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCS 88

  Fly   223 ------QKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLV 281
                  |.:.||..:..|.:      ||.        .||||||||:|.|.:..:::  :..|:|
Mouse    89 QDAARGQAVNDLITNRKEKI------HLE--------FSEDCLYLNIYTPADFSKNS--RLPVMV 137

  Fly   282 YLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWI 346
            ::||...:....:.:||..||:|..|:||.:.|||.:.||.... |.|:..|:..|||:|||||:
Mouse   138 WIHGGGLKLGGASSFDGRALSAYENVVVVAIQYRLSIWGFFSTG-DEHSRGNWGHLDQVAALHWV 201

  Fly   347 KENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQ 411
            ::||..||||...||:.|.|.|...|:.|::||::..||||||..||.|......:.....:|.|
Mouse   202 QDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPITEQ 266

  Fly   412 IAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALT--------------QFSTSLGPIV 462
            ||....|      :.....|::.|:|.:..:::|.|...|.              ||.||   ::
Mouse   267 IAVTAGC------KTTTSAVIVHCMRQKTEEELLEIMHKLNLYKLSLQGDTKNSDQFVTS---VL 322

  Fly   463 DGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA--LEEGLRENERDNLLRFYMQSR 525
            ||.|:|..|.:::..  ::|:....:.||.:.|....|..:.  |...::.:::..:......:.
Mouse   323 DGVVLPKDPKEILAE--KNFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQFAS 385

  Fly   526 FDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMY 590
            ....|:..:...::||....::|.:.     |:.|||.:.|.....|.:.....|.|.....|||
Mouse   386 MTGIPEDIIPVAVEKYTKGSDDPDQI-----REGVLDAMGDVAFGVPSVIVSRGHRDTGAPTYMY 445

  Fly   591 VFG-HNSATGPFAHLPHSIMG---EELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFV 651
            .:. :.|.:.|  ..|.:::|   :::..:||||:...|.      :.:|..||:.||.:|.||.
Mouse   446 EYQYYPSFSSP--QRPKNVVGDHADDVYSVFGAPILREGA------SEEEINLSKMVMKFWANFA 502

  Fly   652 KTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKEL 714
            :.|||..  ||:   .|          ||::::: :.||:||.......:.::..:.||.:.|
Mouse   503 RNGNPNG--KGL---PH----------WPKYDQK-EGYLHIGGTTQQAQRLKEEEVTFWTQSL 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	160/577 (28%)
		Aes	<263..>408	CDD:223730	54/144 (38%)
Ces1f	NP_659179.1	COesterase	24..545	CDD:278561	160/577 (28%)
		Aes	<121..>225	CDD:223730	41/106 (39%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	558..561

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810