Protein Alignment Nlg1 and NLGN1

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 954
• Identity: 265/954 - (27%)
• Similarity: 405/954 - (42%)
• Gaps: 233/954 - (24%)

  Fly   146 HVVPDKLQYTQE-IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQ 209
            ||:..||..... :....|::.||.:... ...|..|.||||:|||..|||.|||.||..|.||.
Human    42 HVLSQKLDDVDPLVATNFGKIRGIKKELN-NEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWS 105

  Fly   210 GLKIARHLPPVCPQ-----KLPD-LSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHE 268
            .::.|....|||||     :||: :.|....|       :|..:..|::.:||||||||:|||.|
Human   106 DIRNATQFAPVCPQNIIDGRLPEVMLPVWFTN-------NLDVVSSYVQDQSEDCLYLNIYVPTE 163

  Fly   269 EPQSTPKQ---------------------YAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTV 312
            :...|.||                     ..|:||:||.|:...:||.||||||:|||.|||:||
Human   164 DGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITV 228

  Fly   313 NYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMV 377
            ||||||||||.....|.. .||.|||.|.||.|..|||..||||..|:|:.|...|.:|||.|.:
Human   229 NYRLGVLGFLSTGDQAAK-GNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTL 292

  Fly   378 SPVA---------SGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLL 433
            |..:         .|||.|||..||:|:|.||.|.|..:....:|..:.|.:::.||      |:
Human   293 SHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVE------LV 351

  Fly   434 DCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYH 498
            :||:.:.|::::.......::..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|...
Human   352 ECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGEGLK 414

  Fly   499 TLAALA-LEEGLRENERDNLLRFYMQSRF------DIRPDLALAATLKKYQDMYNNPIKATNLE- 555
            .:..:. .::|:..::.|..:..::.:.:      |:     |..|:|   .||.:.....|.|
Human   415 FVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDV-----LRETIK---FMYTDWADRHNPET 471

  Fly   556 HRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAP 620
            .|..:|.:.:|.:.|.|.:.|...|::.....|.|.|.|:..|........:..|:|:.::.|.|
Human   472 RRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIP 536

  Fly   621 LAAAGP---FPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP----WKGIFINSHALEWDRYDLD 678
            :  .||   ||. |::..:.:||..||.|||||.|||:|..|    .|.|....:..|    ::.
Human   537 M--IGPTELFPC-NFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVA 594

  Fly   679 WPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELP--DELNQIAAIQEQLQK-PGQEVITGHM 740
            |..::::.|.||:||:.|.|...||...:|.|.:.:|  ..||.|:.......| |..::
Human   595 WTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDI----- 654

  Fly   741 SKYGPRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDL 805
                           |.:          ||:.            |:.|
Human   655 ---------------TFR----------PTRK------------NSVP----------------- 665

  Fly   806 VTSTNSLESGEDHPQAP-PETVAKSEATMQL--LIALITIIIVLNLLIYGTFLLRQRRRRAKALP 867
            |||.......:|..|.| |.:|.:.:.:.:|  .||:...::.||:|.:.....::.:||
Human   666 VTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRR----- 725

  Fly   868 FPAPKLGGTILSYDGANDEELKRCSKSR---------DGDDSFVLEMTRKSNTYEAIKTGQRSLS 923
                             .:..:|||..|         ..::...|:|......:|
Human   726 -----------------HDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHE---------- 763

  Fly   924 CSTVDTHTKVCEWMSSQEAPKSGSFNTATPPPQPILSDGRLIICQDIEVADAALLIPQHMH---- 984
            |.::..|..|              ..||.||      |..|.:.:..:  |..|:.|..:.
Human   764 CESIHPHEVV--------------LRTACPP------DYTLAMRRSPD--DVPLMTPNTITMIPN 806

  Fly   985 -----EPQH-YEMLLQRQHSALTEPSDEILQQQYPLRNHSHSHS 1022
                 :|.| :......|::.|..|        :|   |.||||
Human   807 TIPGIQPLHTFNTFTGGQNNTLPHP--------HP---HPHSHS 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	203/604 (34%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	203/605 (34%)