DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and NLGN4Y

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001352513.1	Gene:	NLGN4Y / 22829	HGNCID:	15529	Length:	836	Species:	Homo sapiens

Alignment Length:	888	Identity:	246/888 - (27%)
Similarity:	388/888 - (43%)	Gaps:	193/888 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 VVPDKLQYTQEIQVKQGRLMGITRRFQVTSG-LRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQG 210
            ::..:.|| ..:....|::.|:  |..:.|. |..|:|:||:|||..|||.|||.||.:|..|.|
Human    38 LIDSQAQY-PVVNTNYGKIQGL--RTPLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTG 99

  Fly   211 LKIARHLPPVCPQKLP------DLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVP--- 266
            ::.|.....||||.|.      |:.|.....       .|..|:.|::.::|||||||:|||
Human   100 IRNATQFSAVCPQHLDERFLLHDMLPIWFTT-------SLDTLMTYVQDQNEDCLYLNIYVPMED 157

  Fly   267 ----------------------HEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIV 309
                                  ||:....|    |:||:||.|:...:||..|||:|:|||.|||
Human   158 GTNIKRNADDITSNDHGEDKDIHEQNSKKP----VMVYIHGGSYMEGTGNMIDGSILASYGNVIV 218

  Fly   310 VTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNY 374
            :|:|||||:||||.....|.. .||.|||||.||.||:||:.|||||..|||:.|...||:||:.
Human   219 ITINYRLGILGFLSTGDQAAK-GNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSL 282

  Fly   375 LMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHR 439
            |.:|..:.|||.:||:.||:|:|.||.:.|..:.|..:|..:.|.:.:..:      :::||:::
Human   283 LTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTD------MVECLKNK 341

  Fly   440 RYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA 504
            .|::::........:..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|      .|.
Human   342 NYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGE------GLK 398

  Fly   505 LEEGLRENER---------------DNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNL 554
            ..:|:.:||.               |||.. |.:.:..:|..:..         ||.:.....|.
Human   399 FVDGIVDNEDGVTPNDFDFSVSNFVDNLYG-YPEGKDTLRETIKF---------MYTDWADKENP 453

  Fly   555 E-HRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFG 618
            | .|..::.:.:|.:.|.|.:.|...||......|.|.|.|:..:........|..|:|:.::||
Human   454 ETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFG 518

  Fly   619 APLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP----WKGIFINSHALEWDRYDLDW 679
            .|:.......|.|::..:.:||..||.|||||.|||:|..|    .|.|....:..|    ::.|
Human   519 IPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVAW 579

  Fly   680 PEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELP--DELNQIAAIQEQLQKPGQEVITGHMSK 742
            .::|.:.|.||:||:.|.|...||...:.||.:.:|  ..||:|........|.....:|..  .
Human   580 SKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSF--P 642

  Fly   743 YGPRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVT 807
            ||.|               :.|:...||     |:..|                        :..
Human   643 YGTR---------------RSPAKIWPT-----TKRPA------------------------ITP 663

  Fly   808 STNSLESGEDHPQAPPETVAKSE------ATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKAL 866
            :.|...|.:.|...|.:|....|      ..:.:.||:...::.||:|.:.....::.:||.:..
Human   664 ANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETH 728

  Fly   867 PFPAPKLGGTILSYDGAND------EELKRCSKSRDGDDSFVLEMTRKSNTYEAIKTGQRSLSCS 925
            ..|:|:...|       ||      ||:            ..|:|.:..:.:|          |.
Human   729 RHPSPQRNTT-------NDITHIQNEEI------------MSLQMKQLEHDHE----------CE 764

  Fly   926 TVDTHTKV---CE---WMSSQEAPKSGSF---NTATPPPQPIL 959
            ::..|..:   |.   .::.:.:|....|   ||.|..|..::
Human   765 SLQAHDTLRLTCPPDYTLTLRRSPDDIPFMTPNTITMIPNTLM 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	198/608 (33%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	75/169 (44%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	196/605 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880