Protein Alignment Nlg1 and CES5A

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 199/635 - (31%)
• Similarity: 298/635 - (46%)
• Gaps: 106/635 - (16%)

  Fly   119 NTTAAVLATD--EGSSEHEPSTTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQV 181
            ::|..||..|  ..:|:.|..:...|:|.    .:|.:   ||.||..::|         ....|
Human    35 SSTLYVLRIDVLNYTSKDEGPSAEGPQRN----TRLGW---IQGKQVTVLG---------SPVPV 83

  Fly   182 DQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHK---H 243
            :.|||:|:|..|.|:.||..|....||..|:.|...|.:|.|        .||.:...:|.   |
Human    84 NVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQ--------NSEWLLLDQHMLKVH 140

  Fly   244 LSRLLPYLRTESEDCLYLNLYVP-HEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEV 307
            ..:.     ..||||||||:|.| |.:   |..:..|||:..|.:|:..|.:.:|||.|::|.:|
Human   141 YPKF-----GVSEDCLYLNIYAPAHAD---TGSKLPVLVWFPGGAFKTGSASIFDGSALAAYEDV 197

  Fly   308 IVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACV 372
            :||.|.||||:.||. .:.|.|...|:|..||:|||.|:::|||.||||.|.||:.|.|.||..|
Human   198 LVVVVQYRLGIFGFF-TTWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISV 261

  Fly   373 NYLMVSPVASGLFHRAILMSGSAMSDWAAS-----NQSLQLTMQIAHALECPLNEHVEAEDDDVL 432
            :.|::||:|.||||:||:.||.|:..:..:     ::.||:   :||.  |..|    |.|.:.|
Human   262 SSLILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDLQV---VAHF--CGNN----ASDSEAL 317

  Fly   433 LDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESY 497
            |.|||.:..:::|    .|:|.:.|...:|||...||:|..::..  :.|.....:.|:...|..
Human   318 LRCLRTKPSKELL----TLSQKTKSFTRVVDGAFFPNEPLDLLSQ--KAFKAIPSIIGVNNHECG 376

  Fly   498 HTLAALALEEGLRENERDNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLD 562
            ..|......|.|..:.: :|....:|:...|.|........:.:.|      |.:..|.||.:||
Human   377 FLLPMKEAPEILSGSNK-SLALHLIQNILHIPPQYLHLVANEYFHD------KHSLTEIRDSLLD 434

  Fly   563 ILSDARVVGPLLQTGMFHADVNRRNYMYVFGHN----SATGP-FAHLPHSIMGEELAFIFGAPLA 622
            :|.|...|.|.|.|..:|.|.....|.|.|.|.    ..|.| |....|:   :|:.|:||
Human   435 LLGDVFFVVPALITARYHRDAGAPVYFYEFRHRPQCFEDTKPAFVKADHA---DEVRFVFG---- 492

  Fly   623 AAGPFPSGNY------TVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPE 681
              |.|..|:.      |.:|||||..:|.||..|.:||||..       |..:|        ||.
Human   493 --GAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPNG-------NDLSL--------WPA 540

  Fly   682 FNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKP 731
            :|...| ||.:.:..::|.:.::..::||...:|    .|.:..:.|..|
Human   541 YNLTEQ-YLQLDLNMSLGQRLKEPRVDFWTSTIP----LILSASDMLHSP 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	184/576 (32%)
		Aes	<263..>408	CDD:223730	64/150 (43%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	187/591 (32%)
		Aes	<155..>258	CDD:223730	47/106 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810