Protein Alignment Nlg1 and Nlgn1

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 974
• Identity: 264/974 - (27%)
• Similarity: 406/974 - (41%)
• Gaps: 253/974 - (25%)

  Fly   146 HVVPDKLQYTQE-IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQ 209
            ||:..||..... :....|::.||.:... ...|..|.||||:|||..|||..||.||..|.||.
Mouse    42 HVLSQKLDDVDPLVTTNFGKIRGIKKELN-NEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWS 105

  Fly   210 GLKIARHLPPVCPQ-----KLPD-LSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHE 268
            .::.|....|||||     :||: :.|....|       :|..:..|::.:||||||||:|||.|
Mouse   106 DIRNATQFAPVCPQNIIDGRLPEVMLPVWFTN-------NLDVVSSYVQDQSEDCLYLNIYVPTE 163

  Fly   269 EPQSTPKQYA-----------------------------------------VLVYLHGESFEWNS 292
            :.:...|:.|                                         |:||:||.|:...:
Mouse   164 DVKRISKECARKPGKKICRKGGPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGT 228

  Fly   293 GNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDN 357
            ||.||||||:|||.|||:||||||||||||.....|.. .||.|||.|.||.|..|||..||||.
Mouse   229 GNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAK-GNYGLLDLIQALRWTSENIGFFGGDP 292

  Fly   358 SRVTLMGHSTGAACVNYLMVSPVA---------SGLFHRAILMSGSAMSDWAASNQSLQLTMQIA 413
            .|:|:.|...|.:|||.|.:|..:         .|||.|||..||:|:|.||.|.|..:....:|
Mouse   293 LRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILA 357

  Fly   414 HALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHY 478
            ..:.|.:::.||      |::||:.:.|::::.......::..:.||::||.|||:.|..:|..
Mouse   358 TKVGCNVSDTVE------LVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIPDDPQILMEQ- 415

  Fly   479 TEHFSRYDLLFGITESESYHTLAALA-LEEGLRENERDNLLRFYMQSRF------DIRPDLALAA 536
             ..|..||::.|:.:.|....:..:. .::|:..::.|..:..::.:.:      |:     |..
Mouse   416 -GEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKDV-----LRE 474

  Fly   537 TLKKYQDMYNNPIKATNLE-HRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGP 600
            |:|   .||.:.....|.| .|..:|.:.:|.:.|.|.:.|...|::.....|.|.|.|:..|..
Mouse   475 TIK---FMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQ 536

  Fly   601 FAHLPHSIMGEELAFIFGAPLAAAGP---FPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP--- 659
            ......:..|:|:.::.|.|:  .||   ||. |::..:.:||..||.|||||.|||:|..|
Mouse   537 VPAWADAAHGDEVPYVLGIPM--IGPTELFPC-NFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQ 598

  Fly   660 -WKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELP--DELNQI 721
             .|.|....:..|    ::.|..::::.|.||:||:.|.|...||...:|.|.:.:|  ..||.|
Mouse   599 DTKFIHTKPNRFE----EVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDI 659

  Fly   722 AAIQEQLQK-PGQEVITGHMSKYGPRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYN 785
            :.......| |..::                    ||:          ||:.            |
Mouse   660 SQYTSTTTKVPSTDI--------------------TLR----------PTRK------------N 682

  Fly   786 APPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQAP-PETVAKSEATMQL--LIALITIIIVLN 847
            :.|                 |||.......:|..|.| |.:|.:.:.:.:|  .||:...::.||
Mouse   683 STP-----------------VTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLN 730

  Fly   848 LLIYGTFLLRQRRRRAKALPFPAPKLGGTILSYDGANDEELKRCSKSR---------DGDDSFVL 903
            :|.:.....::.:||                      .:..:|||..|         ..::...|
Mouse   731 ILAFAALYYKKDKRR----------------------HDVHRRCSPQRTTTNDLTHAPEEEIMSL 773

  Fly   904 EMTRKSNTYEAIKTGQRSLSCSTVDTHTKVCEWMSSQEAPKSGSFNTATPPPQPILSDGRLIICQ 968
            :|......:|          |.::..|..|              ..||.||      |..|.:.:
Mouse   774 QMKHTDLDHE----------CESIHPHEVV--------------LRTACPP------DYTLAMRR 808

  Fly   969 DIEVADAALLIPQHMH---------EPQH-YEMLLQRQHSALTEPSDEILQQQYPLRNHSHSHS 1022
            ..:  |..|:.|..:.         :|.| :......|::.|..|        :|   |.||||
Mouse   809 SPD--DIPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHP--------HP---HPHSHS 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	201/624 (32%)
Nlgn1	XP_006535478.1	COesterase	52..646	CDD:395084	201/625 (32%)