Protein Alignment Nlg1 and cest-13

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_741921.1
• Gene: cest-13 / 181493
• WormBaseID: WBGene00010116
• Length: 548
• Species: Caenorhabditis elegans
• Alignment Length: 555
• Identity: 144/555 - (25%)
• Similarity: 235/555 - (42%)
• Gaps: 109/555 - (19%)

  Fly   155 TQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPP 219
            |.::.|:........|..|.|.|    ..|.|:.||:.|.|..||   ||         ||.|.|
 Worm    22 TYDVTVQTPNGSATIRGIQHTYG----TSFRGIRYAQPPVGLFRF---GA---------ARRLDP 70

  Fly   220 VCPQKLPDLSPHGS---ENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLV 281
            |   .|.:...:|:   :...|..|              ||||::|:|.|:...|::  :..|.|
 Worm    71 V---GLVEAQAYGNICVQGDGRTSH--------------EDCLFINVYTPNNVTQAS--KLPVYV 116

  Fly   282 YLHGESFEWNSGNPYDGSV--LSSYGEVIVVTVNYRLGVLGFL------RPSIDAHNIANYALLD 338
            |:||..|....||...|..  |.:.|.:::|::|||||..||.      .|       .|:|:.|
 Worm   117 YIHGGGFVEGGGNMGAGIYPNLVNKGPIVMVSINYRLGPFGFFSTRQMTAP-------GNWAISD 174

  Fly   339 QIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAA-- 401
            .|.||:|::..|..||||.:|||:.|.|:||..|:.|.::|:|..||.::|..||||..  ||
 Worm   175 WIEALNWVQRYISFFGGDPNRVTIGGQSSGAEAVSTLTLTPLAKNLFKQSIHESGSAFG--AAVM 237

  Fly   402 --SNQSLQLTMQIAHALECPLNEHVE-AEDDDVLLDCLRHRRYQDIL---------HIPTALTQF 454
              |.::...:.|::..|.|..::..: .:....:|.|||:..|..|:         .:..::.|.
 Worm   238 SYSEKTRSTSKQLSIKLGCATSDQWDNGQSFGTILTCLRNVTYDKIVAADNSLPGHRMKWSIVQD 302

  Fly   455 STSLGPIVDGHVIPNQPYK--VMGHYTEHFSRYDLLFGITESESYHTLAALALEEGLRENERDNL 517
            :..|...::...:...|.|  ::|...:.:..:::...:....|.|..|         ...||:|
 Worm   303 NKYLTQRLEYLALQRDPKKNVLIGDVHDEWLGWEMNNVLHNINSSHNTA---------HQMRDDL 358

  Fly   518 LRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVV---LDILSDARVVGPLLQTGMF 579
            ...|..:.:|.:..:.:||..|     |.|....|:..||:..   :.:.|:...:||.|:...:
 Worm   359 SGSYEMTYWDNKQSVLVAADNK-----YINNQGWTDDNHREWEARRIQLWSEMVFIGPTLRDAAY 418

  Fly   580 HADVNRRNYMYVFGHNS------ATGP-FAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEK 637
            ...:....|:|.....|      .|.| |....|:   .||.:||.   .:...|   ..|.|::
 Worm   419 FQYMKNNVYLYSLDWLSPPALPLVTDPLFRGCEHT---WELQYIFS---TSCNGF---TCTAQDE 474

  Fly   638 LLSEAVMAYWTNFVKTGNP-----KAPWKGIFINS 667
            :|.......|.||:..|||     ..|:|.:.::|
 Worm   475 ILRNYFTTTWLNFIIGGNPTPAGSPLPFKWLAMDS 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	143/553 (26%)
cest-13	NP_741921.1	alpha/beta hydrolases	24..526	CDD:473884	143/553 (26%)