DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and cest-9.1

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001359584.1	Gene:	cest-9.1 / 181383	WormBaseID:	WBGene00007692	Length:	614	Species:	Caenorhabditis elegans

Alignment Length:	785	Identity:	170/785 - (21%)
Similarity:	274/785 - (34%)	Gaps:	255/785 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 KLQYTQEIQVKQGRLMGIT-------RRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPW 208
            :.|..:.||...|:|.|||       .|:          .|..:|:|:.|.||.||..|..|..|
Worm    14 QFQSLKVIQTSYGKLRGITVWSNDKNHRY----------MFKSVPFAKPPVGNLRFAKPQNPESW 68

  Fly   209 QGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQST 273
            .|:..|....|.|         ..:.:.:....||.          ||||||:|::...:...|
Worm    69 SGILDASKYSPAC---------MSNSSSTSTPQKHY----------SEDCLYINIFTSEKCLNS- 113

  Fly   274 PKQYAVLVYLHGESFEWNSGNPY-DGSVLSSYG--EVIVVTVNYRLGVLG--FLRPSIDAHNIAN 333
              :..|:||.||.::..:|...: |..:|..|.  :|:.|....||||.|  :..|| |..: .|
Worm   114 --KCPVIVYFHGGAYNLDSAIMFNDTFILDRYAAEDVVFVIPAVRLGVFGQLYFGPS-DLLS-EN 174

  Fly   334 YALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYL----MVSPVASGLFHRAILMSGS 394
            ..|.|.:.||.::...|..||||:.|||.||||:|...|:.|    ::.|... ||.:.|::|.:
Worm   175 LFLYDAVQALSFVHSEINYFGGDSKRVTAMGHSSGGTIVDALGFSKLIDPGVK-LFQQMIVLSAT 238

  Fly   395 AM---SDWAASN--------------QSLQLTMQIAHALECP----------LNEHVEAEDDDVL 432
            .|   .|....|              :..:....||..|:|.          :..|:|..||
Worm   239 GMFGFYDMVVDNSFAIVEKFGCYNGTKDDRPNANIAEMLDCMRQIDGREMLLMQRHMEEVDD--- 300

  Fly   433 LDCLRHRRYQDILH-IPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESES 496
                  |.::.:|. .|     |..|.|.|.|....|.             || :||:|.||.|.
Worm   301 ------RDFRSVLRGAP-----FLESNGKIADLKKSPP-------------SR-NLLYGTTEHEF 340

  Fly   497 YHTLAALALEEGLRENERDNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE---HRD 558
            .:.               |::..:......|....:|:|    :|   |:..:.| |||   :.|
Worm   341 RNV---------------DHMNPYISGIFLDFDNPVAVA----RY---YDEQLMA-NLETMINGD 382

  Fly   559 VVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAA 623
            .....:..:.....:..||   |||      |:|.....       |:|....::.:..|.....
Worm   383 AAAIFICASTFSTAMANTG---ADV------YLFETRQK-------PYSFHVSDMQYFVGIHREI 431

  Fly   624 AGPFPSGNY---------TVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDW 679
                    |         |...|||        .||.|.|.|...|.              .||.
Worm   432 --------YHRPDMDILDTFYSKLL--------VNFTKMGVPSPEWA--------------PLDP 466

  Fly   680 PEFNRRAQAYLNIGIP------PTVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQEVITG 738
            ...|     ||.:.:.      |.:...:.:..|..|..|:.:....:..|::....|.:.:...
Worm   467 ERMN-----YLELKVDSDMKEGPVMLEGFHEKEMELWFGEMMEFDRNVTKIRQSQGLPPEHLDIE 526

  Fly   739 HMSKYGPRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFE 803
            ...||....:              :|.:...|..|                |..:|:    .:..
Worm   527 TQLKYWETTN--------------KPEILTKTTKG----------------FTSIHQ----DNNS 557

  Fly   804 DLVTSTNSLESGEDHPQAPPETVAKSEATM------QLLIALITIIIVLNLLIYGTFLLRQRRRR 862
            :.||:|.|.:|          ::.|:.:::      .|:|.|:.:::||.::..      ::.:|
Worm   558 NTVTTTASAQS----------SLLKNGSSILKQWWFYLIIFLMILLVVLIVICL------RKPKR 606

  Fly   863 AKALP 867
            .:.||
Worm   607 EEELP 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	145/618 (23%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	48/170 (28%)
cest-9.1	NP_001359584.1	Abhydrolase	19..498	CDD:389770	144/615 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810