Protein Alignment Nlg1 and cest-19

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_509187.4
• Gene: cest-19 / 180973
• WormBaseID: WBGene00020125
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 612
• Identity: 167/612 - (27%)
• Similarity: 260/612 - (42%)
• Gaps: 123/612 - (20%)

  Fly   145 RHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQ 209
            ||:.|      .|::|..|.:.|  .|. :|.| :....|.|:|:|..|.|..||..|..|..|:
 Worm    21 RHISP------FELRVNSGAIRG--ERL-LTDG-QDYSVFKGIPFAMPPVGYLRFQMPKEPAKWR 75

  Fly   210 GLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTP 274
            |:..|.....:|.|.:       .||.:....::::.:       ||||||||::.|      ||
 Worm    76 GVMNATQYSAMCMQNI-------DENDAGEPERYVAHV-------SEDCLYLNVFSP------TP 120

  Fly   275 KQYA-----VLVYLHGESFEWNSGNPY-DGSVLSSY--GEVIVVTVNYRLGVLGFLRPSIDAHNI 331
            .||.     |:|::||..|:..||:.. ..::||::  .:::.||.|||||.|||.... |:...
 Worm   121 YQYTNDTYPVIVFIHGGRFQTGSGSDIPQRAILSNFVSRKIVFVTFNYRLGPLGFASTG-DSVLP 184

  Fly   332 ANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAM 396
            .|..|.|||.||.|:|.|.|.||||.|.:.||||.||||..:.|.:||.|.|||.:.:||||||:
 Worm   185 GNIGLWDQIWALKWVKANAEVFGGDPSNILLMGHGTGAASASLLALSPRAEGLFQKVLLMSGSAL 249

  Fly   397 SDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPI 461
            ......|..:..|..:.....|      .|.:...||||.|.|..::|...............||
 Worm   250 QPGVVRNTQVNATWNMNDRFGC------RAFNSSELLDCARKRSKEEIFQYKRLHFDDYEEFVPI 308

  Fly   462 VD--GHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEEGLRENERD-NLLRFYMQ 523
            :|  |.::|..|.::    |.|..:..::.|.|:.||  :|..|.|      ||:| |......:
 Worm   309 IDGVGGILPEPPEQL----TLHRRKTPIVIGTTKDES--SLRILLL------NEKDLNFSSITWE 361

  Fly   524 SRFDIRPDLALAATLKKYQDMYNNPIKATNLEHR-------------------------DVVLDI 563
            :...:..:|.|.  .|::|:            ||                         :.:|.:
 Worm   362 NGETLADNLTLG--FKQFQN------------HRLISQGCKSEYVWTQVDPSFPESVLFNSLLKM 412

  Fly   564 LSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFP 628
            .|......|..|...::...:...|:|.|.|.|..  |..:..:..|.:...||...........
 Worm   413 YSHFWYDAPASQLATYYLKHDLPVYLYSFDHISEN--FYDIDRAFHGVDKLHIFNVTPRFLNKRK 475

  Fly   629 SGNYTVQEK---LLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYL 690
            ..|:.:.::   :.||.|    .||...|.|          :|  |.|.:..:|.....:..:||
 Worm   476 DMNWQLDQRVVEIFSELV----ANFALYGTP----------TH--ENDGFSFNWTSTTAKELSYL 524

  Fly   691 NIGIPPT--VGYKYR-QIYMNFWNKEL 714
            :|...|:  |||::: .::.|::.:.|
 Worm   525 SITDSPSMQVGYRWQGHVFWNWYARSL 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	163/594 (27%)
cest-19	NP_509187.4	alpha/beta hydrolases	24..544	CDD:473884	163/600 (27%)