DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and glit-1

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_508807.1	Gene:	glit-1 / 180747	WormBaseID:	WBGene00018878	Length:	730	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	162/577 - (28%)
Similarity:	242/577 - (41%)	Gaps:	88/577 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 FLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLL 248
            |||:||||.||..|||.||      |.|       .|.|.|.|.|:.:.:.:.::...|..|..:
Worm   109 FLGVPYAEPPTSQRRFKPP------QQL-------TVFPGKQPYLAFNYAASCAQDVEKSPSPFV 160

  Fly   249 --PYLRTESEDCLYLNLYVP--HEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIV 309
              ||.....|||||||::.|  .:..|:|   |.|:|:.||.:|:..|.|.:....|:|.| ::|
Worm   161 DHPYPFMVDEDCLYLNIFSPDISKNAQTT---YPVIVFFHGGNFQTGSANEWPAHGLASRG-MVV 221

  Fly   310 VTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNY 374
            ||||||||..||:  |:......||.|.||..||.::|.||..||||...||::||..|||.:.:
Worm   222 VTVNYRLGAFGFM--SMGDSETGNYGLQDQRLALEFVKNNIVTFGGDPQAVTVVGHDAGAASIGF 284

  Fly   375 LMVSPVASGLFHRAILMSGSAMSDWAASNQ---SLQLTMQIAHALEC--PLNEHVEAEDDDVLLD 434
            .|.||.:..||..|..|||:.:|..:...:   :...||::.....|  .:.:|        ..|
Worm   285 HMQSPYSRHLFRSAATMSGAEVSYHSYIGKTALAFNNTMKLGRYAGCTQAVAQH--------RWD 341

  Fly   435 CLRHRRYQDIL----HIPTALTQFSTSLGPIVDGHVIPNQPYKVM----GHYTEHFSRYDLLFGI 491
            |:..|...||:    :||....::  ...|.|||..:|..|...:    ...|...|...:|.|:
Worm   342 CILTRSTGDIIDATRNIPIEYNRY--LFMPTVDGKYLPGNPLWTLVNAPSGETSIMSPVPMLIGM 404

  Fly   492 TESE-SYHTLAALALEEGLRENERDN------LLRFYMQSRFDIRPDLALAATLKKYQDMYNNPI 549
            ...: |...|....|.|..:.|:.|:      .|.:..:..:.:..:....|.|.||...   |.
Worm   405 NAQDGSEVVLEDRRLGEFSQFNDVDHEYLKSYSLEYCYRHNYSMNREATADAILSKYTFW---PD 466

  Fly   550 KATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHN-SATGPFAHLPHSIMGE-- 611
            :|.....::..:...:||....|:..:...|:....|.:.||..:| |...|........||.
Worm   467 RAAAWAIKENFIQFATDAYYTAPMQLSSHLHSSSGSRVFQYVNNYNFSRQHPNLLFIPDWMGVCR 531

  Fly   612 --ELAFIFGAPLAAAGPFPSG----NYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHAL 670
              :|..:||.|.......|.|    |:|..::..|.........|....||..
Worm   532 DCDLYLMFGYPFLPDELRPIGLRGINFTDTDRNASRTFSNIIRRFSYHQNPNF------------ 584

  Fly   671 EWDRYDLDWPEFNRRAQAYLNIG--------IPPTVGYKYRQIYMNFWNKELPDELN 719
               ::|..|..:..|...|:|..        ||.|:...||...:.|||:.:|..:|
Worm   585 ---QFDGSWAAYEPRRHWYINFNYTHEEDWKIPGTLARDYRYQDVAFWNEYIPALVN 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	157/566 (28%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	57/149 (38%)
glit-1	NP_508807.1	COesterase	56..629	CDD:365897	157/566 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880