Protein Alignment Nlg1 and cest-2.3

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_506510.2
• Gene: cest-2.3 / 179918
• WormBaseID: WBGene00013873
• Length: 665
• Species: Caenorhabditis elegans
• Alignment Length: 740
• Identity: 171/740 - (23%)
• Similarity: 291/740 - (39%)
• Gaps: 145/740 - (19%)

  Fly   152 LQYTQEIQVKQGRLMG-ITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIAR 215
            |..:..||:..|.:.| |........|.:....|||:||.|.|.|..||..|.....|:|:...:
 Worm    14 LSISTRIQLSTGTIEGKILNATYSPFGNQTATVFLGIPYVEPPIGELRFRKPRLLKSWEGVLETK 78

  Fly   216 HLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVL 280
            ...|.|              ||..|....:..:..:   ||||||.|::......|:  |..:|:
 Worm    79 DYKPAC--------------MSYWRKTFKNGFVGEI---SEDCLYANVFTNQYCLQN--KNCSVM 124

  Fly   281 VYLHGESFEWNSGNPYDGSVL--SSYGE---VIVVTVNYRLGVLGF--LRPSIDAHNIANYALLD 338
            :.:||......||:.:...:.  :..|:   ::|||.||||||.||  ........|:|.|   |
 Worm   125 IVVHGGRLVCESGSAFKPEIFINNFVGQDRNIVVVTFNYRLGVFGFGVFNGETGDTNVAMY---D 186

  Fly   339 QIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASN 403
            .:.|:.|:::.|:.|||:..|:|:.|||.||..:.....|.::.||.|:.|:|| :.:.|.:.|.
 Worm   187 MLEAVKWVRKEIDQFGGNKDRITMAGHSAGAGLIVDFTSSTLSKGLLHQQIVMS-APLQDISKSA 250

  Fly   404 QSLQLTMQIAHALECPLNEH-----VEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSL--GPI 461
            ....:|: :|..:.|...|:     .:.:.:...| ||:::..||:||...::.|.||..  .|.
 Worm   251 NFKGMTI-VAQNVGCIPKEYGFRKLSKTQINKTYL-CLQNKSAQDLLHAQLSMQQNSTFYFGSPR 313

  Fly   462 VDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAAL-ALEEGLRENERDNLLRFYMQSR 525
            |||..|.:.|..:....|.:  ..:...|.|..|...:|... ...:.::|....|:........
 Worm   314 VDGDFITDYPDNLFNFNTIY--PINTFIGTTTGELRDSLYITDPKNDRIKEQLLKNMCEHVGYEL 376

  Fly   526 FDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMY 590
            |: :|:    ...||..:.|.|...|..|.         .|.......::....|...|.:.:||
 Worm   377 FE-KPE----EFTKKCGNYYKNGTDAQFLS---------DDMEFYSGAIKVANAHKRANSKVFMY 427

  Fly   591 VFGHNSATGPF-----AHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNF 650
            .:.:..|...|     |..||.  .|:|.:.||   .:.|||.:.:|.: |::.|..:    .||
 Worm   428 SYDYKGAGTAFHKYLEAPSPHH--SEDLIYTFG---TSRGPFVAKDYVI-ERIYSGML----ANF 482

  Fly   651 VKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYL-----NIGIPPTVGYKYRQIYMNFW 710
            :...:|..        |...:|.:|..:..|:      :|     |..:|....:.|.:. ::||
 Worm   483 INFEDPSP--------SKTQQWRQYTQEKREY------FLIDFDKNFTMPGMKDHYYTRA-LDFW 532

  Fly   711 NKELPDELNQIAAIQEQLQKPGQEVITGHMSKYGPRDHGAEDPVRTLKLLLQEPSL-------AG 768
            :                         |.....:..|...:.|  ..:..:|.:|.:       :|
 Worm   533 S-------------------------TAGKKSFSERFSPSLD--NFVMSILTDPIVSHLKGVASG 570

  Fly   769 PTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDL--VTSTNS-LESGEDHPQAPPETVAKSE 830
            |.:|.|.    .|.::|...:|....|::.....|..  |...|| :|..:|..|.....|
 Worm   571 PDKSIEQ----FEKVFNERESFLEELKLRRKLKLEKKIGVQMRNSVVEFEKDADQGTSGGV---- 627

  Fly   831 ATMQLLIALITIIIVLNLLIYGTFL 855
                    |.|:.|:|.:.::|:.:
 Worm   628 --------LNTLPIILGVTVFGSII 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	142/578 (25%)
cest-2.3	NP_506510.2	alpha/beta hydrolases	17..532	CDD:473884	142/580 (24%)