Protein Alignment Nlg1 and cest-2.1

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_506508.2
• Gene: cest-2.1 / 179916
• WormBaseID: WBGene00013875
• Length: 675
• Species: Caenorhabditis elegans
• Alignment Length: 596
• Identity: 138/596 - (23%)
• Similarity: 247/596 - (41%)
• Gaps: 112/596 - (18%)

  Fly   152 LQYTQEIQVKQGRLMG--ITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIA 214
            :..:..:|:..|.:.|  :|..:........:. |||:|:.|.|.||.||..|..|:||.|:...
 Worm    15 ISISTRVQLSTGTIEGKILTSTYSPLGNHTGIG-FLGIPFVEPPAGNLRFRKPRPPIPWDGILET 78

  Fly   215 RHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQY-- 277
            :...|.|              ||.|:..:.:.:...:   ||||||.|::.         .||
 Worm    79 KEYKPAC--------------MSDAKKTYKNGVGGPI---SEDCLYANVFT---------NQYCM 117

  Fly   278 -----AVLVYLHGESFEWNSGNPYDGSVL--SSYGE---VIVVTVNYRLGVLGFLRPSIDAHNIA 332
                 :|::.:||......|.:.::..:|  :..|:   ::|||.|||||..||...:.:..: :
 Worm   118 KRKNCSVMIVVHGGRILTESASAFNPEILVNNFVGQGRNIVVVTFNYRLGTFGFGVLNGEKGD-S 181

  Fly   333 NYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMS 397
            |..:.|.:.|:.|.::.:..|||:..::|::|||.|.:.|.....||::.|:.::.|:|||:...
 Worm   182 NVGMFDMLEAVKWTRKEVHNFGGNKDKLTMVGHSAGGSLVGAFTSSPLSKGMLNQQIIMSGALYQ 246

  Fly   398 DWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLD----CLRHRRYQDILHIPTALTQFST-- 456
            ....:|......|  |....|........:...|.:|    |||:...|::|.....:.|.:|
 Worm   247 MGKLANFKGMTAM--AQKAGCLPEVFGFRKLSQVRIDKTYSCLRNISAQEVLDAQLWVLQNTTYY 309

  Fly   457 -SLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEEGLRENERDNLLRF 520
             |: |.:||..:.|...:::...|.|  ..:.:.|.|.:|....:....|:...::.|....|..
 Worm   310 ISV-PHIDGEFLLNYSDEILASGTIH--PINSMIGTTTAELRDPIYINDLKNADKKEELLKNLCE 371

  Fly   521 YMQSRFDIRPDLALAATLKKYQDMYNN----PIKATNLEHRDVVLDILSDARVVGPLLQTGMFHA 581
            ::.......|:    ...:|.|..|.|    ...|.::|..|..:.:.:             .||
 Worm   372 HIGYELYTEPE----EFSRKCQKFYGNGDDAQFLADDMEFYDGSIKVAN-------------AHA 419

  Fly   582 DVNRRNYMYVFGHNSATGP----FAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEA 642
            ..|.:.:||.:.:..| ||    :|..|.....|:|.::||.        ..||:|.::.::.:.
 Worm   420 SKNTKVFMYSYDYKDA-GPAFKKYAQAPPPHHSEDLIYVFGT--------SRGNFTEKDYVIEQI 475

  Fly   643 VMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYL------NIGIPPT-VGY 700
            ....:.:||..||| :|.|              :..|.|::...:.|.      |..:|.| .||
 Worm   476 YSGMFADFVNFGNP-SPSK--------------EQKWKEYSPEKREYFLIDFDKNFTMPGTRDGY 525

  Fly   701 KYRQIYMNFWN 711
            ..|.  :.||:
 Worm   526 YSRA--LEFWS 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	136/588 (23%)
cest-2.1	NP_506508.2	COesterase	18..533	CDD:395084	136/590 (23%)