Protein Alignment Nlg1 and cest-1.1

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_506506.1
• Gene: cest-1.1 / 179915
• WormBaseID: WBGene00011362
• Length: 673
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 149/589 - (25%)
• Similarity: 249/589 - (42%)
• Gaps: 112/589 - (19%)

  Fly   166 MGITRRFQVTSGL---------------RQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIAR 215
            |.:.:|.|::||.               :....|||:|:.|.|.|:.|:..|..|..|:|:.:..
 Worm    13 MYVCKRVQLSSGTIEGKILNISYSPLGNQSATVFLGIPFVEPPIGDLRYRKPRPPKSWEGVLVTN 77

  Fly   216 HLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVL 280
            .....|              ||.|...:.::   :....||||||||:..  .|.....|..:|:
 Worm    78 EYKSAC--------------MSNATKTYKNK---FGGPISEDCLYLNVLT--NEYCLENKNCSVM 123

  Fly   281 VYLHGESFEWNSGNPYDGSVL--SSYGE---VIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQI 340
            :.:||..:...|.:.::..:|  :..|:   ::|||.|||||:..|.:.:.|..: .|:.|.|.|
 Worm   124 MIVHGGGYLTESASTFNPEILINNFVGQGRNIVVVTFNYRLGLFSFGQFNGDRGD-KNFGLYDMI 187

  Fly   341 AALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQS 405
            .:::|::..||.|||:.:|:||.|||.||:.:.....||:..||.|:.|:|| :.|::.:..:..
 Worm   188 ESVNWVRREIENFGGNKNRITLAGHSAGASMIVAFTSSPLTKGLVHQQIIMS-APMTNMSKKSNF 251

  Fly   406 LQLTMQIAHALECPLNEHV-----EAEDDDVLLDCLRHRRYQDILHIPTALTQFST-SLG-PIVD 463
            ..:|: :|..:.| |:|.:     ..|..:....|||.:..|.||.....|.|.|| .|| |.:|
 Worm   252 KGMTV-MAQMVGC-LSEEIGFNKLSEEQVENTYSCLRKKSAQQILDAQLWLLQNSTYFLGAPPID 314

  Fly   464 GHVIPNQPYKVMGHYTEHFSRYDLLFGIT----ESESYHTLAALALEE-GLRENERDNL--LRFY 521
            .|.:.:.|..:  :.::.....:.|.|.|    |..||....|.|.:: .|.||..|::  :.:.
 Worm   315 EHFLTDYPENL--YASKSIYPINTLIGTTTLEVEESSYIIDPAFADKKVELLENLCDHIGYVLYE 377

  Fly   522 MQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRR 586
            ....|.           ||.|..|.|...:.||.         ::.....|.:.....|...|.:
 Worm   378 EPETFS-----------KKCQKQYMNGNSSMNLS---------NEMEFYTPAIDFADSHTSGNTK 422

  Fly   587 NYMYVFGHNSATGPF------AHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMA 645
            .::|.:.:..| ||.      ...||.  .|:|.::||   ...|.|...:|.: ||:.|    .
 Worm   423 VFLYSYDYRGA-GPAYDRYLEVRSPHH--SEDLIYVFG---THRGIFAPKDYII-EKIYS----G 476

  Fly   646 YWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIG---IPPTVGYKYRQIYM 707
            .:.:||...||        :.|...:|::|..:     .|....:|..   |.|.:...|.....
 Worm   477 MFADFVNFENP--------LPSGDQKWNQYTKE-----NREHFLINFDKNFITPGMRDNYYTEAY 528

  Fly   708 NFWN 711
            .||:
 Worm   529 EFWS 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	147/586 (25%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:395084	145/580 (25%)