Protein Alignment Nlg1 and cest-1.2

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 605
• Identity: 147/605 - (24%)
• Similarity: 239/605 - (39%)
• Gaps: 145/605 - (23%)

  Fly   168 ITRRFQVTSGLRQVDQ---------------FLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHL 217
            |:.:.|:::|:.:..|               |||:||.|.|.|:.||..|.....|.|:...:..
 Worm    17 ISTKVQLSTGIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDLRFRKPRPQKTWSGVLETKKF 81

  Fly   218 PPVCPQKLPDLSPHGSENMSRARHKHLSRLL--PYLRTESEDCLYLNLYVPHEEPQSTPKQY--- 277
            .|.|              ||.:...:.:..:  |.    ||||||||:..         .||
 Worm    82 KPAC--------------MSNSTKTYKNGGIGGPI----SEDCLYLNVLT---------NQYCLE 119

  Fly   278 ----AVLVYLHGESFEWNSGNPYDGSVL--SSYGE---VIVVTVNYRLGVLGFLRPSIDAH---- 329
                :|::.:||..:.:.|...::..:|  :..|:   ::|||:|||||:.||      .|
 Worm   120 NKNCSVVIIVHGGGYLFESAATFNHEILVNNFVGQDRNIVVVTINYRLGIFGF------GHLNGF 178

  Fly   330 -NIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSG 393
             ...|..:.|.:.|:.|::..|:.|||:..|:||.|||.||..|....:||:..||.|:.|:|||
 Worm   179 EGDKNVGIFDTLEAVKWVRREIKQFGGNKDRITLAGHSAGAGVVAAFTISPLTKGLIHQQIVMSG 243

  Fly   394 SAMSDWAASNQSLQLTMQI----AHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQF 454
             .|::.:..:....:|...    .|:.:...|:..|.|.:.| ..|||.:..|::|.....|.|.
 Worm   244 -PMTNMSKKSNFKGMTAMAERVGCHSKKYGFNKLPEHEVEQV-YSCLRKKPAQELLDAQLWLLQN 306

  Fly   455 STSL--GPIVDGHVIPNQPYKVMGHYTEH--FSRYDLLFGITESE-------SYHTLAALALEEG 508
            ||..  .|.|||..|.:.|..:   |:|.  || .:.|.|.|..|       |....:....:|.
 Worm   307 STFYFGAPPVDGEFITDYPDNL---YSEKSIFS-INTLLGTTTRELQDTGYISNSNYSKFETKET 367

  Fly   509 LRENERDNL-LRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGP 572
            ..:|..|.: :..|.:|.     |.:     .|.|..|.|...:.:|.         .|......
 Worm   368 FLKNLCDQIGIEIYKESE-----DFS-----SKCQKWYINGSDSKSLS---------DDMEFYTQ 413

  Fly   573 LLQTGMFHADVNRRNYMYVFGHNSATGPF-----AHLPHSIMGEELAFIFGAPLAAAGPFPSGNY 632
            .:.....||...::.|||.:.::.|...|     ...||.  .|:|.:.||   ...|.|...:|
 Worm   414 AINLADAHARKGKKVYMYSYAYSGAGPAFKKYMKVKSPHH--SEDLIYTFG---THRGVFAPKDY 473

  Fly   633 TVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYL------N 691
            .::  .:...:.|.:.|| :..:|..                 |..|.::.:..:.|.      |
 Worm   474 VIE--YIYSGMFADFINF-EDPSPST-----------------DQPWLQYTKENKEYFLVDFDQN 518

  Fly   692 IGIPPTVGYKYRQIYMNFWN 711
            :.:|......|.:.| .||:
 Worm   519 LTMPGMKKNYYAKAY-EFWS 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	145/602 (24%)
		Aes	<263..>408	CDD:223730	46/161 (29%)
cest-1.2	NP_506504.2	COesterase	21..536	CDD:278561	144/598 (24%)
		Aes	<125..>250	CDD:223730	44/131 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810