Protein Alignment Nlg1 and cest-17

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_505114.1
• Gene: cest-17 / 179198
• WormBaseID: WBGene00019477
• Length: 571
• Species: Caenorhabditis elegans
• Alignment Length: 605
• Identity: 149/605 - (24%)
• Similarity: 244/605 - (40%)
• Gaps: 128/605 - (21%)

  Fly   157 EIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVC 221
            ::....|.::|...:..||.....|  |||:.|...|....||..|.....|
 Worm    23 KVTTPYGPIVGFEHKSTVTGSKYHV--FLGIRYGNPPDHIYRFQKPEPVEKW------------- 72

  Fly   222 PQKLPDLSPHGSENMSRARHKHLSRLLPYLRTE-------SEDCLYLNLYVPHEEPQSTPKQYAV 279
                    ||.:.:.:..|    :..:|.||:|       |||||:||:..|   |.:..|:..|
 Worm    73 --------PHINHDATHFR----ASCIPSLRSELEEQVNYSEDCLFLNIVTP---PDAKEKKLPV 122

  Fly   280 LVYLHGESFEWNSGNPYDGSVLSSY--------GEVIVVTVNYRLGVLGFLRPSIDAHNIANYAL 336
            ||::||..|::.     |.|::...        .::|.|::.||||.|||.... |:....|..|
 Worm   123 LVFIHGGGFQFG-----DTSMIGYQKAADNFVSKDIIFVSIQYRLGPLGFFTTG-DSEIPGNMGL 181

  Fly   337 LDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAA 401
            .||..||.::.|.:..||||..|:||.|||.|||.|:.|:.||.:..||.:||.:|||..|:...
 Worm   182 WDQTLALQFLHEVLPDFGGDPDRITLAGHSAGAASVSALLYSPHSDHLFSQAIQLSGSIFSESNL 246

  Fly   402 SNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHV 466
            ....:..:.::|.|..||      .||...|.||:..|...::|       ....|:|.::.|
 Worm   247 DRNVVDDSRKLAKAAGCP------QEDSKELRDCIEIRTVDELL-------DAMESIGELLPG-- 296

  Fly   467 IPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAAL-ALEEGL---------------REN--- 512
              .:..|...::.:.|..||:.....::....|:..| :||.||               :|:
 Worm   297 --PRTKKFHPYFDKDFFPYDIEKMSRKAPKKRTMQGLVSLESGLSVLYPVKLAKLLGVPKESWST 359

  Fly   513 -ERDNLLRFYMQSRFDIRPDLALAATLKK--YQDMY-NNPIKATNLEHRDVVLDILSDARVVGPL 573
             .:|||:.| ::|:..:..:...|:....  .::.| :.|:...:..:.:...::|||.:...|.
 Worm   360 YSKDNLVDF-IRSQVAVEQEFGTASARFSGLVEEFYLSGPMTGNSSFYLNAFANLLSDLQYNIPT 423

  Fly   574 LQTGMFHADVNRRNYMYVFGHNSAT---------GPFAHLPHSIMGEELAFIFGAPLAAAGPFPS 629
            |.............|:|:..::|.|         |||    |:   .||.::|........||..
 Worm   424 LHEVELKLQHGWDTYLYIIDYDSETTKDPTHPIKGPF----HA---SELRYLFNFNGMDTIPFND 481

  Fly   630 GNYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGI 694
            .:...:...::..|     ||:.||.|         ::.||.|.......|..|      |.:..
 Worm   482 KDKKFENYFVNAIV-----NFINTGTP---------STKALLWPAVSKSQPFAN------LLLND 526

  Fly   695 PPTVGYKYRQIYMNFWNKEL 714
            .|:|...:||.....|..::
 Worm   527 KPSVQTSFRQEAYELWQSDI 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	148/599 (25%)
		Aes	<263..>408	CDD:223730	53/152 (35%)
cest-17	NP_505114.1	COesterase	20..542	CDD:278561	148/599 (25%)
		Aes	<109..>225	CDD:223730	44/124 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810