Protein Alignment Nlg1 and cest-33

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_504621.1
• Gene: cest-33 / 179020
• WormBaseID: WBGene00017431
• Length: 554
• Species: Caenorhabditis elegans
• Alignment Length: 565
• Identity: 145/565 - (25%)
• Similarity: 232/565 - (41%)
• Gaps: 85/565 - (15%)

  Fly   146 HVVPDKLQYTQEIQVKQGRLMG-ITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQ 209
            |:.|:  |..:.::...|.:.| |.:...|.     ||.:||:|||:.|.|..||..|.....|.
 Worm     7 HLTPE--QNVEALKASCGPVRGNIYKHDDVI-----VDGYLGIPYAKPPVGELRFKKPVTVDVWT 64

  Fly   210 GLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTP 274
            .:|......|.|.|      ..|.|.::..|..         ..|...||.||::.|........
 Worm    65 EIKDCYKYGPACVQ------TGGFEQIAGPRTP---------TPEEAGCLTLNVFTPRNASSEFK 114

  Fly   275 KQYAVLVYLHGESFEWNSGNPYDGSVLSS---YGEVIVVTVNYRLGVLGFLRPSIDAHNI--ANY 334
            ....|:||:||..:|..:.:.:....||.   ..:|:||::||||||.|||   ....|:  .|:
 Worm   115 NGRPVMVYIHGGGYELCASSDFCAYSLSGTLPLKDVVVVSINYRLGVFGFL---TTGDNVCPGNF 176

  Fly   335 ALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDW 399
            .|.||..||.|::::|.:||||.:.||:.|.|.|.|..:.|.:||.:..||.|.|.:||:|..|:
 Worm   177 GLWDQTLALKWVQKHISSFGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDF 241

  Fly   400 A--ASNQSLQLTMQIA--HALECPLNEHVEAEDDDVLLDCLRHRRYQDILHI---PTALTQFSTS 457
            |  ||....::..:.|  |..        ...|...|....:.:..:.:.::   ..:::.|.|.
 Worm   242 AIRASENQAKIFREFAEFHGF--------SGRDSSALFKWYQEQSPETLSNVKGYKKSISGFLTF 298

  Fly   458 LGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEEGLRENERDNLLRFYM 522
            : |.:||...|    |.:....:...:..::.|:||   |..|...::....  :..|..|....
 Worm   299 I-PNLDGDFFP----KPLDELRKEAPKKQMMTGVTE---YEGLMLASMNPAF--SPADVGLTLMP 353

  Fly   523 QSRF--DI--RPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADV 583
            |..:  |:  .||.......:||.:..:   |:..|..|..:.:.|.|......::|.....|..
 Worm   354 QGIYGKDVVSNPDEIQKIFYEKYVEGVD---KSDELAMRKKLCEALGDEFFNVGVIQAAKNAAKH 415

  Fly   584 NRRNYMYV--------FGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLS 640
            ....|.|.        ||......||....|.   .||.::.|     .|.:.....|.:::.:.
 Worm   416 GNEVYFYTFEYVNPDSFGMWDGMMPFKAAVHC---TELRYLLG-----EGVYSKFEPTEEDRKVM 472

  Fly   641 EAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRR 685
            |.....::||.|.|||..  ||    :.|..|::|.|:.||.:.|
 Worm   473 ETTTTLFSNFAKYGNPNG--KG----ATAEIWEKYSLNRPERHYR 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	142/554 (26%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	142/554 (26%)