Protein Alignment Nlg1 and cest-24

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_504613.1
• Gene: cest-24 / 179017
• WormBaseID: WBGene00020891
• Length: 658
• Species: Caenorhabditis elegans
• Alignment Length: 641
• Identity: 188/641 - (29%)
• Similarity: 267/641 - (41%)
• Gaps: 153/641 - (23%)

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQV-DQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVC 221
            ::|:||.|.|    |:|.:....: |.|.|:||||.|.|..||..|..|..|:|::.....|
 Worm    98 VRVQQGLLEG----FRVKTAKGDLCDVFHGIPYAEPPVGELRFQKPQPPKAWEGIRKCNKYP--- 155

  Fly   222 PQKLPDLSPHGSENMSRARHKHL--SRLLPYLRTESEDCLYLNLYVP--HEEPQSTPKQYAVLVY 282
                           :|:.||.:  .:.|| ...:||||||||::.|  .|:     |:|.||.|
 Worm   156 ---------------NRSIHKEMPWDKALP-SANQSEDCLYLNVFAPKIRED-----KKYPVLFY 199

  Fly   283 LHGESFEWNSGNPYDGSVLSSY---GEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALH 344
            :||..:..:|...|....:...   .|:||||.:||||.||||....|... .||.|.|.:.|:.
 Worm   200 IHGGGYVMDSAERYTAKNICKLLVSREIIVVTFHYRLGFLGFLSTGDDVCP-GNYGLFDMLEAMR 263

  Fly   345 WIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWA-ASNQSL-Q 407
            |:..||.:||||...:||.|.|.|||..:.|..||:..|||.|.|:|.|::...|| .||..: :
 Worm   264 WVHANISSFGGDPENITLSGQSAGAAAADLLSFSPLTKGLFKRKIVMGGNSYCHWATTSNHDIRE 328

  Fly   408 LTMQIAHALEC-PLNEHVEAEDDDVLLDCLRHRRYQDILH----IPTA---LTQFSTS------- 457
            ...:.|..|.. |...:....::.|           ||.:    :||:   :|.|.::
 Worm   329 YCKKWAKRLGWKPQLNYANKREESV-----------DIFNFFNGLPTSKLGMTMFFSNTIFKECQ 382

  Fly   458 --LGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEEGLRENER------ 514
              |.|::||.::|:. .||:....||...   |.|..|.|:. ...|:.|   ||..|:
 Worm   383 LPLAPVIDGEILPHD-LKVLRETQEHVPS---LVGGGEYEAL-LFCAIGL---LRGTEKEINSAI 439

  Fly   515 DNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTG-- 577
            |.|.|....||..|.     |.|.|.|.|  :..::|.:...:...:.::||.     ....|
 Worm   440 DVLSRKNRLSRSKIE-----AMTEKVYGD--SPALRADSKARKMFFVQLISDI-----FANYGNY 492

  Fly   578 MFHADVNRRN---YMYVFGHNSA--------TGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSG- 630
            .|..|..:|.   |.|.|.|.|.        ..||....|:   .||:::|.....:|   |.|
 Worm   493 RFMRDCQQRGVECYGYSFDHQSKQMWGWLQHVVPFTGGTHT---SELSYLFDCNYMSA---PLGM 551

  Fly   631 NYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIP 695
            |.|  :|::|.....|:|||||.|.|..|      ||...:|:|...|......       |.|.
 Worm   552 NKT--DKVVSGMTADYFTNFVKFGTPNGP------NSQLPKWERISPDDEHMKL-------ISIK 601

  Fly   696 P-----TVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQEVITGHMSKYGPR 746
            |     |..|.||.  .||     .|.|..   :.|:..|          |.:.||
 Worm   602 PEPEMKTTVYGYRM--QNF-----EDHLGM---LYEEKDK----------SPFSPR 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	180/603 (30%)
cest-24	NP_504613.1	COesterase	97..608	CDD:395084	175/590 (30%)