DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and cest-6

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_501070.1	Gene:	cest-6 / 177459	WormBaseID:	WBGene00020688	Length:	583	Species:	Caenorhabditis elegans

Alignment Length:	593	Identity:	133/593 - (22%)
Similarity:	229/593 - (38%)	Gaps:	142/593 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 VTSGLRQVD--------QFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSP 230
            :|:.|..::        .|..:|:|:.|.|..||..|.|...|:|:..|....|.|
Worm    26 ITTSLGSINGNQIGSYQTFKKIPFAKPPIGKLRFQKPMAAEKWEGILNATEYGPAC--------- 81

  Fly   231 HGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNSGNP 295
            ..:.:.|::..|.:          .||||::|::.  .:...:.|..:|:.|:||....::|...
Worm    82 MSNSSTSKSPQKWI----------DEDCLHINIFT--TDTCLSSKNCSVVFYVHGGELVYDSAVM 134

  Fly   296 YDGSVL---SSYGEVIVVTVNYRLGVLGFLRPSIDAHNIA--NYALLDQIAALHWIKENIEAFGG 355
            ::...|   .|..:||:|...:|||:  |....::..|:|  |.||.|.:.||.::|..|..|||
Worm   135 FEDKYLFDTFSSRDVILVIPAFRLGL--FSHFVVEDQNVAPNNLALYDILLALEFVKSEIHNFGG 197

  Fly   356 DNSRVTLMGHSTGAACVNYLMVSPVAS---GLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALE 417
            .:.|||..|||.|...|:.:..|...:   ..|.|.|.|  |:::.|.:....::.||:......
Worm   198 SSDRVTAFGHSYGGHVVSVMAFSTEINTDLSYFQRVICM--SSVNVWDSLEFEIEKTMRFIQYAN 260

  Fly   418 CPLNEHVEA-----EDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPN---QPYKV 474
            |.:.:.:::     |.|..:::||:.....::|.|..:|....   .||..|.|:..   |...|
Worm   261 CSVPQDLKSRMTSFEQDSYMMECLQDIDSMELLRIQRSLEDEG---HPIYSGLVLREPLIQNVLV 322

  Fly   475 MGHYTEHFSRYDLLFGITESE-----SYHTLAALALEEGLRENE---RDNLLRFYMQSRFDIRPD 531
            ...| |.......|.|.|..|     :||.:......|..:|.:   ||:  |.|  .|||:.
Worm   323 QDFY-EKPKNIPTLTGCTYKELDKFHAYHNIVETLGYENYKECDDKYRDD--RKY--GRFDLN-- 380

  Fly   532 LALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARV-VGPLLQTGMFHADVNRRNYMYVFGHN 595
                                   :|.|....||:..:: |...|..|:       ..|.|.:.:.
Worm   381 -----------------------KHADETFGILAQTKLKVDKQLDKGI-------PTYFYEYSYP 415

  Fly   596 SATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAPW 660
            .      |..|:   ::|::|.|     ...|......:.   |:::....:.||||.|.|...:
Worm   416 K------HPSHT---DDLSYIMG-----VHAFEKDENEIH---LAKSYQEMFMNFVKFGEPGGGF 463

  Fly   661 K-GIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYK------YRQIYMNFWNKELPDEL 718
            : ..|.||                    :|.|.....|.|.|      :.:..:.:|.|::.:..
Worm   464 EMSTFENS--------------------SYFNFYWNETTGEKSSMKTNFEKEIIKYWLKDMFEYD 508

  Fly   719 NQIAAIQE 726
            ..|.|.::
Worm   509 QNITAAKQ 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	129/575 (22%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	43/152 (28%)
cest-6	NP_501070.1	Abhydrolase	25..500	CDD:389770	129/575 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810