Protein Alignment Nlg1 and cest-4

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_501043.1
• Gene: cest-4 / 177445
• WormBaseID: WBGene00015930
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 611
• Identity: 146/611 - (23%)
• Similarity: 241/611 - (39%)
• Gaps: 147/611 - (24%)

  Fly   165 LMGITRRFQVTSGLRQVD--------QFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVC 221
            |..||:...|::.|.|:|        .|..:|.|:.|.|..||..|..|..|.|::.|:...|.|
 Worm    20 LFSITKSAIVSTSLGQIDGDQIGSFHLFKHIPLAKPPIGKLRFQKPEPPEKWTGVRNAKAYGPAC 84

  Fly   222 ---------PQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQY 277
                     |||..|                            ||||::|::...:..:|  |..
 Worm    85 ISNSSVSTSPQKWID----------------------------EDCLHINIFTSDKCLKS--KDC 119

  Fly   278 AVLVYLHGESFEWNSGNPYDGSVL--SSY-------GEVIVVTVNYRLGVLGFLRPSIDAHNIA- 332
            ||:.|.||      .|..||.:|:  .:|       .:||:....:|||:  |....::..:||
 Worm   120 AVVTYFHG------GGLMYDSAVMFNDTYLLGTFVNQDVIIAIPAFRLGI--FSHFVVEDQSIAP 176

  Fly   333 -NYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVAS---GLFHRAILMSG 393
             |.||.|.:..:.::|..|..|||:|.:.|:||||.|.:.||.|..|...:   .||.::|.||.
 Worm   177 TNLALYDILLGVEFVKNEIHNFGGNNQKNTIMGHSYGGSIVNILTFSSKINHDLSLFQQSICMSS 241

  Fly   394 SAMSDWAASNQSLQLTMQIAHALECPLNEHVE-----AEDDDVLLDCLRHRRYQDILHIPTALTQ 453
            .  .|:......:|.|.:.|....|.:...:|     .:.|...:.||:::...::|.:...|
 Worm   242 G--HDFETLEIQIQKTNRFAKHAGCTVPSIIEKKMTTRQSDLYRMKCLQNKDALELLRVQRLL-- 302

  Fly   454 FSTSLGPIVDGHVIPNQPYKVMGHYTEHF---SRYDLLFGITESESYHTLAALALEEGLR-ENER 514
              ...|....|:::..:|......|.|..   .:..:|.|.|..|..|:.|...:.:.|. ||..
 Worm   303 --EDEGYPTYGYLVQREPLIQEIPYQEFMKSPKKIPMLTGCTRYEMDHSPAPKPIGQALGFENPE 365

  Fly   515 DNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARV-VGPLLQTGM 578
            :    .||:.|.|...::        |:  :.|        |.|....|:...|| |..||..
 Worm   366 E----VYMKFRKDWDDEV--------YE--FGN--------HSDETQAIMVQVRVRVNNLLSK-- 406

  Fly   579 FHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAV 643
                 |...|:|.:     |.| .|..|:   ::|.::.|     ...|......::   |.:..
 Worm   407 -----NVPAYLYEY-----TYP-KHARHT---DDLFYLMG-----VHRFEKDENEIE---LGKVY 449

  Fly   644 MAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMN 708
            ...:.||.|.|:||   :| |..::|.....|::.|..         ..|..|.:..|:.:..:|
 Worm   450 ETIFMNFAKFGDPK---EG-FELANAENESYYEVYWDG---------ETGERPQMKTKFEEKIIN 501

  Fly   709 FWNKELPDELNQIAAIQEQ---LQKP 731
            :|.|::.:....|..::.|   ::||
 Worm   502 YWLKDMVEYDKHITELKNQKISIRKP 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	140/585 (24%)
cest-4	NP_501043.1	alpha/beta hydrolases	26..503	CDD:473884	137/579 (24%)