Protein Alignment Nlg1 and cest-5.1

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_501022.3
• Gene: cest-5.1 / 177429
• WormBaseID: WBGene00015279
• Length: 580
• Species: Caenorhabditis elegans
• Alignment Length: 585
• Identity: 125/585 - (21%)
• Similarity: 223/585 - (38%)
• Gaps: 146/585 - (24%)

  Fly   184 FLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVC---------PQKLPDLSPHGSENMSRA 239
            |..:|:|:.|.||.||..|.|...|.|::.|....|.|         |||..|
 Worm    39 FKKIPFAKPPVGNLRFQKPEAAGKWDGIRSAIEYGPACMSNSSKTKSPQKWVD------------ 91

  Fly   240 RHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSS- 303
                            ||||::|::...:..:|  :..|:.||:||....::|...::.:||..
 Worm    92 ----------------EDCLHVNIFTSKKCLKS--RNCAIAVYIHGGGLTYDSAVMFNDTVLLDT 138

  Fly   304 --YGEVIVVTVNYRLGVLGFLRPSIDAHNIA--NYALLDQIAALHWIKENIEAFGGDNSRVTLMG 364
              ..:||:|...:|||:  |...::...|:|  |.||.|...||.::|..|.:|||::.::||.|
 Worm   139 FVKRDVILVIPGFRLGI--FSHFTVHNQNVAPNNLALYDITLALEFVKSEIHSFGGNSQKITLFG 201

  Fly   365 HSTGAACVNYLMVSPVAS---GLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVE- 425
            ||.|....:.:..|...:   .||.:||:|||...  :......::.|.:......|.:...:|
 Worm   202 HSYGGGLASMMTFSSEINRDLSLFQQAIVMSGGFY--FEELKDHIEGTKRFVEYANCSVPLKLER 264

  Fly   426 ----AEDDDVLLDCLRHRRYQDILHIPTALTQ----------FSTSLGPIVDGHVIPNQPYKVMG 476
                ::.:..::.||:.....::|.|...|..          ....|.|.|....:...|..:
 Worm   265 KMERSQQEMYMMKCLQKLSGMELLRIQRLLEDKGYPDFGGVILREPLFPDVKKFELLKSPKNI-- 327

  Fly   477 HYTEHFSRYDLLFGITESESYHTLAALALEEGLRENERDNLLRFYMQSRFDIRPDLALAATLKKY 541
                     .:|.|.|..|..|        |.::       :.|.....|: .||        :.
 Worm   328 ---------PMLTGCTNLEFDH--------ESIK-------VPFGKYLEFE-NPD--------EC 359

  Fly   542 QDMYNNPIKA---TNLEHRDVVLDILSDARV-VGPLLQTGMFHADVNRRNYMYVFGHNSATGPFA 602
            .:.|.|.:::   ....|.|....|:...:: :..||:.       |...|:|         .:.
 Worm   360 DEKYRNDVESGVENRGNHTDKTQGIILPLKLQINNLLEN-------NVTAYLY---------EYT 408

  Fly   603 HLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQ-EKLLSEAVMAYWTNFVKTGNPKAPWKGI-FI 665
            :..|....::|::|.|     ...|......|. |::..:.|:    ||:|.|.|     |: |.
 Worm   409 YPKHGRHTDDLSYIMG-----VHAFEKDENEVHLEQVYKDMVI----NFIKLGEP-----GMGFE 459

  Fly   666 NSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQK 730
            .|...|...:|:.|.|         ..|..|.:...:.:...::|.||:.:...::...:::|::
 Worm   460 KSEQNESTYFDIYWNE---------TTGERPRMRKYFEKEVTDYWLKEMIEFDQKVTETKKKLKQ 515

  Fly   731  730
             Worm   516  515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	121/563 (21%)
cest-5.1	NP_501022.3	alpha/beta hydrolases	17..495	CDD:473884	121/563 (21%)