Protein Alignment Nlg1 and cest-25

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_497609.1
• Gene: cest-25 / 175390
• WormBaseID: WBGene00022178
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 645
• Identity: 162/645 - (25%)
• Similarity: 248/645 - (38%)
• Gaps: 185/645 - (28%)

  Fly   130 GSSEHEPSTTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPT 194
            |.:..:.:|.|:|..|.|:           ...|.:.|  ||. :..|.:|||.|.|:|||..|.
 Worm     2 GGTVSKHTTPHYPPSRQVL-----------TSYGPIEG--RRL-IHEGEKQVDAFQGIPYAAPPI 52

  Fly   195 GNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCL 259
            ||.||..|.....|..::              :....|:..:.:   .|:  |.|....:|||.|
 Worm    53 GNLRFALPQPHEKWTEVR--------------ETKSFGARGIQK---DHV--LSPKTSPQSEDNL 98

  Fly   260 YLNLYVPHEEPQSTPKQ---YAVLVYLHGESFEWNSGNPYDGSVLSSY---GEVIVVTVNYRLGV 318
            .||::.    |..|||.   :.|::|:||..|..:|.:.|....:..:   .:|:|||:.||||.
 Worm    99 TLNIFT----PVWTPKNETGFPVILYIHGGGFVSDSAHKYGDMSICQHLVTKDVVVVTIQYRLGF 159

  Fly   319 LGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASG 383
            |||.... |:....|.||.|.:.||.|:||||..|.||.:.:||||.|.|.|.|::|.:|||:..
 Worm   160 LGFWTTG-DSSIPDNVALHDMVFALKWVKENIGLFNGDPNNITLMGQSAGGASVDFLSISPVSRD 223

  Fly   384 LFHRAILMSGSAMSDWAASNQSLQLTMQIAHAL----------------ECP-------LN-EHV 424
            ||.:.|.|.|:|...||...:.|......|..:                |.|       || |.|
 Worm   224 LFQKVIPMGGNASCSWAIHPRPLNACRNRAQEIGVFDGMNTLDWVEKLRELPADKFASALNMEAV 288

  Fly   425 EAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLL- 488
            :.:.|..||                        :||..|...||.   .||....|...:..||
 Worm   289 DTKTDPELL------------------------IGPKYDNLFIPR---PVMELRKEAPMKPRLLG 326

  Fly   489 -----------FGITESESYHT----LAALALE---------------EGLRENERDNLLRFYMQ 523
                       ||:......|.    ::|:..|               |.|.|...|:....:.:
 Worm   327 CAKSEGLVFAFFGLNTKHPLHAVQQDVSAILSEKLFPLKARDYQEKALEKLIEIGTDHSKEEWQR 391

  Fly   524 SRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNY 588
            :..|::.|..|                  |:..:..|||:| :.:...|:              |
 Worm   392 AMVDLKGDSFL------------------NVGIQQNVLDVL-ETQPSTPI--------------Y 423

  Fly   589 MYVFGH--NSATG------PFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMA 645
            ||.|.:  ..|.|      ||....|.   .:::::.|..:..:..|...:|    |:: |....
 Worm   424 MYSFDYCNPKAYGIMGFKLPFKDATHC---TDISYVVGNHIVNSFDFNEEDY----KMI-EITTR 480

  Fly   646 YWTNFVKTGNPKAPWKGIFINSHALE-WDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQ 704
            .||||.|.|||......:   :|..| |:...::.|      |.::.:.:.|.:.:.|:|
 Worm   481 LWTNFAKYGNPNGEGDDV---AHLEEKWEPATIESP------QTHMALTLQPKLHHVYKQ 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	156/622 (25%)
		Aes	<263..>408	CDD:223730	58/150 (39%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	157/629 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810