Protein Alignment Nlg1 and cest-27

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_871861.2
• Gene: cest-27 / 171610
• WormBaseID: WBGene00018958
• Length: 561
• Species: Caenorhabditis elegans
• Alignment Length: 547
• Identity: 148/547 - (27%)
• Similarity: 225/547 - (41%)
• Gaps: 118/547 - (21%)

  Fly   181 VDQFLGLPYAEAPTGNRRFMPPGAPLPW-QGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHL 244
            |:.|||:||||.|.|..||..|.|...| :.|...|..|         .||...|        .|
 Worm    48 VEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGP---------RSPQNDE--------LL 95

  Fly   245 SRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYG---- 305
            .:.:..:....|.||.||::.|..|....|..:.|:|::||..|..:|.        |:||
 Worm    96 GQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFAVHSS--------SNYGCASI 152

  Fly   306 -------EVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLM 363
                   :|:|||:|||||||||.... |.....|..|.||.|||.|::|||::|.||...||:.
 Worm   153 ARNLCTKDVVVVTINYRLGVLGFFTTG-DEVCRGNLGLWDQTAALEWVQENIQSFRGDPDNVTIF 216

  Fly   364 GHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWA--ASNQSLQLTMQIAHALECPLNEHVEA 426
            |.|.|.|.|:.|.:||.:.|||:|||.|:|:...|:|  .|.|..||:.:.|..|..      |.
 Worm   217 GQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAQLSREFARYLGW------EG 275

  Fly   427 EDDDVLLDCLRHRRYQDILHIPTALTQFSTSLG------------------PIVDGHVIPNQPYK 473
            :|:|          .:|:|........:...:|                  |..||...|    |
 Worm   276 DDND----------SEDLLQFIDQQPLYKIEMGINPKRGFKHSQAGSLYFVPNFDGDFFP----K 326

  Fly   474 VMGHYTEHFSRYDLLFGITESESYHTLAALALE---EGLRENERDNLLRFYMQSRFDIRPDLALA 535
            .:....:...:..::.|.|:.|....:|..||.   ||:::    .:.|.:.:..:..|.|
 Worm   327 PLNQLRKEAPKMQIMTGTTKYEGLFFIALGALSKNPEGIKK----FMGRIFKECDYGERAD---- 383

  Fly   536 ATLKKYQDMYNNPIKATNLE---HRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSA 597
            ..|:...|.|...:...:.|   |:  ::..:.|..:.....:......|:....|.|.|.::::
 Worm   384 DVLQMVYDFYFKGVHPKDHEKNMHQ--IVKFIGDYSINYGTYRLANIMTDLQHDVYFYQFDYHNS 446

  Fly   598 TG--------PFAHLPHSIMGEELAFIFGAPLAAAGPF-PSGNYTVQEKLLSEAVMAYWTNFVKT 653
            .|        ||....|.   .|:.::.|..:.:  .| |:.|    :|.:...:..|:|||.|.
 Worm   447 AGFGVFRWLLPFLGSTHC---TEMRYVLGKGIIS--KFRPNDN----DKKMLHVMTTYFTNFAKY 502

  Fly   654 GNPKAPWKGIFINSHALEWDRYDLDWP 680
            |||...      |....||.::|...|
 Worm   503 GNPNGE------NQETGEWQKHDSAHP 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	148/547 (27%)
cest-27	NP_871861.2	COesterase	29..548	CDD:395084	148/547 (27%)