DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_599163.2	Gene:	Nlgn3 / 171297	RGDID:	621119	Length:	848	Species:	Rattus norvegicus

Alignment Length:	794	Identity:	245/794 - (30%)
Similarity:	372/794 - (46%)	Gaps:	147/794 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 GRLMGITRRFQVTSG-LRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLP 226
            |:|.|  .|..:.|. |..|||:||:|||..|.|.:||:||..|..|.|::.|.|.||||||.:.
  Rat    49 GKLRG--ARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIH 111

  Fly   227 DLSPHGSENMSRARH-KHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYA------------ 278
            ...|   |.|..... .:|..:..|::..:|||||||:|||.|:.:...|:.|
  Rat   112 TAVP---EVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGG 173

  Fly   279 ----------------------------VLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYR 315
                                        |:||:||.|:...:||..|||||:|||.|||:|:|||
  Rat   174 SGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYR 238

  Fly   316 LGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPV 380
            :||||||.....|.. .||.|||||.||.|:.|||..||||..|:|:.|...||:||:.|.:|..
  Rat   239 VGVLGFLSTGDQAAK-GNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHH 302

  Fly   381 ASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDIL 445
            :.|||.|||:.||||:|.||.:.|.::.|..:|..:.|.:.:.|:      ::||||.:..::::
  Rat   303 SEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVD------MVDCLRQKSAKELV 361

  Fly   446 HIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA-LEEGL 509
            .......::..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|....:..:. .|:|:
  Rat   362 EQDIQPARYHVAFGPVIDGDVIPDDPEILMEQ--GEFLNYDIMLGVNQGEGLKFVEGVVDPEDGV 424

  Fly   510 R--------ENERDNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILS 565
            .        .|..|||.. |.:.:..:|..:..         ||.:.....|.| .|..::.:.:
  Rat   425 SGTDFDYSVSNFVDNLYG-YPEGKDTLRETIKF---------MYTDWADRDNPETRRKTLVALFT 479

  Fly   566 DARVVGPLLQTGMFHADVNRRNYMYVFGHN------SATGPFAHLPHSIMGEELAFIFGAPLAAA 624
            |.:.|.|.:.|...||......|.|.|.|:      .|....||      |:|:.::||.|:  .
  Rat   480 DHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAH------GDEVPYVFGVPM--V 536

  Fly   625 GP---FPSGNYTVQEKLLSEAVMAYWTNFVKTGNPK--APWKGIFINSHALEWDRYDLDWPEFNR 684
            ||   ||. |::..:.:||..||.|||||.|||:|.  .|....||::.|..::  ::.|.::|.
  Rat   537 GPTDLFPC-NFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFE--EVAWSKYNP 598

  Fly   685 RAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELN-----QIAAIQEQLQKPGQEVITGHMSKYG 744
            |.|.||:||:.|.|...||...:.||...:|...|     ...:...::..|.    |.|.|...
  Rat   599 RDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPD----TTHSSHIT 659

  Fly   745 PRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTST 809
            .|.:|     :|..  .:.|::: |..|.|          |||.::      .|..|...|:
  Rat   660 RRPNG-----KTWS--TKRPAIS-PAYSNE----------NAPGSW------NGDQDAGPLL--- 697

  Fly   810 NSLESGEDHPQAPPETVAKSEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPAPKLG 874
              :|:..|:           ...:.:.||:...::.||:|.:.....|:.:||.:.|..|:|:.|
  Rat   698 --VENPRDY-----------STELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRG 749

  Fly   875 GTILSYDGANDEEL 888
            ........|.:|||
  Rat   750 TGAPELGTAPEEEL 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	206/609 (34%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	76/184 (41%)
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	206/609 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..195		0/25 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..691		15/73 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780