DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	182/615 - (29%)
Similarity:	282/615 - (45%)	Gaps:	102/615 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 GSSEHEPS---TTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAE 191
            |....|.|   |||..:    |..||.:.::  .|.|                 |..|||:|:|:
  Rat    26 GQDSPESSSIRTTHTGQ----VRGKLDHVRD--TKAG-----------------VHTFLGIPFAK 67

  Fly   192 APTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESE 256
            ||.|..||.||..|.||.|::.....|.:|.|.:..|...|..:|     |.:...:|.    ||
  Rat    68 APVGPLRFAPPEDPEPWSGVRDGTSHPAMCLQNIDMLDEVGLTDM-----KMILSSIPM----SE 123

  Fly   257 DCLYLNLYVP-H-EEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVL 319
            ||||||:|.| | .|..:.|    |:|.:||.:......:..|||:|:...:::||.:.||||||
  Rat   124 DCLYLNIYTPAHAHEGSNLP----VMVCIHGGALVIGMASMCDGSLLAVNEDLVVVAIQYRLGVL 184

  Fly   320 GFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGL 384
            ||.... |.|...|:..|||:|||.|:::||..|||:.:|||:.|.|.|...|:..::||::.||
  Rat   185 GFFSTG-DEHARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHVISPMSQGL 248

  Fly   385 FHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPT 449
            ||.||:.||.|:.....|..|..::..:|....|      ||.|.:.|:.|||.:...:||
  Rat   249 FHGAIMESGVALLPDLISETSETVSTTVAKLSGC------EATDSETLVRCLRAKSGAEIL---- 303

  Fly   450 ALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTL-AALALEEGLRENE 513
            .:.:....:..:|||..:|..|.:::.  :|.|.....:.|:...|...|: ..:...:.::|..
  Rat   304 VINKVFKMIPAVVDGEFLPRHPKELLA--SEDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELS 366

  Fly   514 RDNLLRFYMQSRFDIR-PDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTG 577
            |:||......:...:. |.......:::|....::| :...:::.:::.|.|    .|.|.||..
  Rat   367 RENLQAVLKDTAAQMMLPPECGDLLMEEYMGNTDDP-QTLQIQYAEMMGDFL----FVIPALQVA 426

  Fly   578 MF---HADVNRRNYMYVFGH-----NSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSG---N 631
            .|   ||.|    |.|.|.|     .:...|.....|:   :|:.|:||:       |..|   :
  Rat   427 HFQRSHAPV----YFYEFQHAPSYFKNVRPPHVKADHA---DEVPFVFGS-------FFWGIKVD 477

  Fly   632 YTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPP 696
            :|.:|||||..:|.||.||.:.|||         ||..|.:      ||..:...| ||.:...|
  Rat   478 FTEEEKLLSRRMMKYWANFARHGNP---------NSEGLPY------WPVLDHDEQ-YLQLDTQP 526

  Fly   697 TVGYKYRQIYMNFWNKELPDELNQIAAIQE 726
            .|....:...:.||.|.||.::.::...|:
  Rat   527 AVDRALKARRLQFWTKTLPQKIQELNGAQK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	167/571 (29%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	58/146 (40%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	174/591 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810