Protein Alignment Nlg1 and Ces3b

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Alignment Length: 587
• Identity: 180/587 - (30%)
• Similarity: 278/587 - (47%)
• Gaps: 90/587 - (15%)

  Fly   157 EIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVC 221
            |:....||:.|  |:..|....|.|:.|||:|:|:||.|..||..|..|.||:|::.|...||:|
Mouse    38 EVDTPLGRVRG--RQVGVKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMC 100

  Fly   222 PQKLPDLSPHGSENMSRARH--KHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLH 284
            .|.:        |.|..:|.  ....::.|.    |||||.||:|.|.|......:  .|:|::|
Mouse   101 LQDV--------EKMINSRFGLNEKIKIFPI----SEDCLTLNIYSPTEITAGDKR--PVMVWIH 151

  Fly   285 GESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKEN 349
            |.|....|....|||.|::||:|:||||.||||:.|||... |.|...|...||.:|||.|::.|
Mouse   152 GGSLLVGSSTSQDGSALAAYGDVVVVTVQYRLGIFGFLSTG-DKHMPGNRGFLDVVAALRWVQGN 215

  Fly   350 IEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSG-------SAMSDWAASNQSLQ 407
            |..||||.:.||:.|:|.|...|:.|.:||:::|||||||..||       ..|..|..:
Mouse   216 IAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMKPWPEA----- 275

  Fly   408 LTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPY 472
              ...|:::.|......|      |:.||..:..:|:      :.|.:.::..||:....|.:|.
Mouse   276 --QNFANSVACGSASPAE------LVQCLLQKEGKDL------IKQKNVNISYIVNDSFFPQRPE 326

  Fly   473 KVMGHYTEHFSRYDLLFGITESE-SYHTLAALALEEGLRENERDNLLRFYMQSR-----FDIRPD 531
            |::.  .:.|.....|.|:|..| .:..|.:|.:.:.|....|::||..   ||     .::.|:
Mouse   327 KLLA--DQQFPTVPYLLGVTNHEFGWLLLKSLNILDKLEHLSREDLLEI---SRPFLAIMEVPPE 386

  Fly   532 LALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNS 596
            : :...:.:|.|..::. .||    |....::|.|...:.|.|....:..|.....::|.|.|..
Mouse   387 I-MPTVIDEYLDNGSDQ-SAT----RYAFQELLGDISFIIPTLNFSKYLRDAGCPVFLYEFQHTP 445

  Fly   597 ATGPFAHL-PHSIMGE---ELAFIFGAPL----AAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKT 653
            ::  ||.. |..:..:   |.:|:||.|.    ::...||..  |.:||.||..:||.|:.|.:|
Mouse   446 SS--FAKFKPAWVKADHASENSFVFGGPFLTDESSLLAFPEA--TEEEKQLSLTMMAQWSQFART 506

  Fly   654 GNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDEL 718
            |||..  ||:             ..||:.|:..| ||.||:....|.|.::..:.||.:.||.::
Mouse   507 GNPNG--KGL-------------PPWPQLNQLEQ-YLEIGLESRTGVKLKKGRLQFWTETLPRKI 555

  Fly   719 NQ 720
            .:
Mouse   556 QE 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	176/575 (31%)
		Aes	<263..>408	CDD:223730	62/151 (41%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	176/575 (31%)
		Aes	75..>245	CDD:223730	72/184 (39%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810