DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	575	Identity:	175/575 - (30%)
Similarity:	279/575 - (48%)	Gaps:	80/575 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQ-VDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVC 221
            :...||:::|   ::....|..| |..|||:|:|:.|.|:.||.||....||..:|.|...||:|
Mouse    26 VDTTQGKVLG---KYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMC 87

  Fly   222 PQK------LPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVL 280
            .|.      |.|:.....|            :|| |:. ||||||||:|.|.:..:|:  |..|:
Mouse    88 SQDAGWAKILSDMFSTEKE------------ILP-LKI-SEDCLYLNIYSPADLTKSS--QLPVM 136

  Fly   281 VYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHW 345
            |::||........:||:|..||::..|:|||:.||||:.|..... |.|:..|:|.|||:|||.|
Mouse   137 VWIHGGGLVIGGASPYNGLALSAHENVVVVTIQYRLGIWGLFSTG-DEHSPGNWAHLDQLAALRW 200

  Fly   346 IKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTM 410
            :::||..|||:...||:.|.|:|...|:.|::||:...||||||..||..::. ....:::|...
Mouse   201 VQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINT-NVGKKNIQAVN 264

  Fly   411 QIAHAL-ECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKV 474
            :|...| :|  |:...|    .::.|||.:...::|.|...|.|::.||..::||.|:|..|.::
Mouse   265 EIIATLSQC--NDTSSA----AMVQCLRQKTESELLEISGKLVQYNISLSTMIDGVVLPKAPEEI 323

  Fly   475 MGHYTEHFSRYDLLFGITESESYHTLAAL---ALEEGLRENERDNLLRFYMQSRFDIRPDLALAA 536
            :..  :.|:....:.|..:.|....:..:   .|.||....|..:||.....|..:|...: :.|
Mouse   324 LAE--KSFNTVPYIVGFNKQEFGWIIPMMLQNLLPEGKMNEETASLLLRRFHSELNISESM-IPA 385

  Fly   537 TLKKYQDMYNNPIKATNLEHRDVVLDILSDA--RVVGPLLQTGMFHADVNRRNYMYVFGHNSATG 599
            .:::|....::|.|.:.|     :||:..|.  .:...||...:..|.|:  .|||.|.:..:
Mouse   386 VIEQYLRGVDDPAKKSEL-----ILDMFGDIFFGIPAVLLSRSLRDAGVS--TYMYEFRYRPS-- 441

  Fly   600 PFA--HLPHSI---MGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP 659
             |.  ..|.::   .|:|:.|:|||||...|.      :.:|..||:.||.:|.||.:.|||
Mouse   442 -FVSDKRPQTVEGDHGDEIFFVFGAPLLKEGA------SEEETNLSKMVMKFWANFARNGNP--- 496

  Fly   660 WKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKEL 714
                  |...|.      .|||::.: :.||.||.......:.:...:.||.:.|
Mouse   497 ------NGEGLP------HWPEYDEQ-EGYLQIGATTQQAQRLKAEEVAFWTELL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	172/569 (30%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	55/144 (38%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	172/560 (31%)
		Aes	<121..>234	CDD:223730	45/115 (39%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810