Protein Alignment Nlg1 and Ces1c

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_031980.2
• Gene: Ces1c / 13884
• MGIID: 95420
• Length: 554
• Species: Mus musculus
• Alignment Length: 575
• Identity: 175/575 - (30%)
• Similarity: 279/575 - (48%)
• Gaps: 80/575 - (13%)

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQ-VDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVC 221
            :...||:::|   ::....|..| |..|||:|:|:.|.|:.||.||....||..:|.|...||:|
Mouse    26 VDTTQGKVLG---KYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMC 87

  Fly   222 PQK------LPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVL 280
            .|.      |.|:.....|            :|| |:. ||||||||:|.|.:..:|:  |..|:
Mouse    88 SQDAGWAKILSDMFSTEKE------------ILP-LKI-SEDCLYLNIYSPADLTKSS--QLPVM 136

  Fly   281 VYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHW 345
            |::||........:||:|..||::..|:|||:.||||:.|..... |.|:..|:|.|||:|||.|
Mouse   137 VWIHGGGLVIGGASPYNGLALSAHENVVVVTIQYRLGIWGLFSTG-DEHSPGNWAHLDQLAALRW 200

  Fly   346 IKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTM 410
            :::||..|||:...||:.|.|:|...|:.|::||:...||||||..||..::. ....:::|...
Mouse   201 VQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINT-NVGKKNIQAVN 264

  Fly   411 QIAHAL-ECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKV 474
            :|...| :|  |:...|    .::.|||.:...::|.|...|.|::.||..::||.|:|..|.::
Mouse   265 EIIATLSQC--NDTSSA----AMVQCLRQKTESELLEISGKLVQYNISLSTMIDGVVLPKAPEEI 323

  Fly   475 MGHYTEHFSRYDLLFGITESESYHTLAAL---ALEEGLRENERDNLLRFYMQSRFDIRPDLALAA 536
            :..  :.|:....:.|..:.|....:..:   .|.||....|..:||.....|..:|...: :.|
Mouse   324 LAE--KSFNTVPYIVGFNKQEFGWIIPMMLQNLLPEGKMNEETASLLLRRFHSELNISESM-IPA 385

  Fly   537 TLKKYQDMYNNPIKATNLEHRDVVLDILSDA--RVVGPLLQTGMFHADVNRRNYMYVFGHNSATG 599
            .:::|....::|.|.:.|     :||:..|.  .:...||...:..|.|:  .|||.|.:..:
Mouse   386 VIEQYLRGVDDPAKKSEL-----ILDMFGDIFFGIPAVLLSRSLRDAGVS--TYMYEFRYRPS-- 441

  Fly   600 PFA--HLPHSI---MGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP 659
             |.  ..|.::   .|:|:.|:|||||...|.      :.:|..||:.||.:|.||.:.|||
Mouse   442 -FVSDKRPQTVEGDHGDEIFFVFGAPLLKEGA------SEEETNLSKMVMKFWANFARNGNP--- 496

  Fly   660 WKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKEL 714
                  |...|.      .|||::.: :.||.||.......:.:...:.||.:.|
Mouse   497 ------NGEGLP------HWPEYDEQ-EGYLQIGATTQQAQRLKAEEVAFWTELL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	172/569 (30%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	172/560 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554