DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Ache

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_036020624.1	Gene:	Ache / 11423	MGIID:	87876	Length:	616	Species:	Mus musculus

Alignment Length:	612	Identity:	201/612 - (32%)
Similarity:	292/612 - (47%)	Gaps:	88/612 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222
            ::|:.|:|.||  |.:...|  .|..|||:|:||.|.|:||||||....||.|:..|.....||.
Mouse    41 VRVRGGQLRGI--RLKAPGG--PVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCY 101

  Fly   223 QKLPDLSP--HGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQS-TPKQYAVLVYLH 284
            |.:..|.|  .|:|..:..|..            ||||||||::.|:..|.| ||    ||::::
Mouse   102 QYVDTLYPGFEGTEMWNPNREL------------SEDCLYLNVWTPYPRPASPTP----VLIWIY 150

  Fly   285 GESFEWNSG----NPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHW 345
            |..|  .||    :.|||..|:.....::|::|||:|..|||..........|..||||..||.|
Mouse   151 GGGF--YSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQW 213

  Fly   346 IKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWA--ASNQSLQL 408
            ::|||.|||||...|||.|.|.|||.|...::|..:..|||||:|.||:....||  ::.::.:.
Mouse   214 VQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRR 278

  Fly   409 TMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDIL----HIPTALTQFSTSLGPIVDGHVIPN 469
            ...:|..:.||...  ...:|..|:.|||.|..||::    |:....:.|..|..|:|||..:.:
Mouse   279 ATLLARLVGCPPGG--AGGNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSD 341

  Fly   470 QPYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEEGLRENERDN-----LLRFYMQSRFDI- 528
            .|..::.  |..|....:|.|:.:.|..:.|.     .|:....:||     ..:|....|..:
Mouse   342 TPEALIN--TGDFQDLQVLVGVVKDEGSYFLV-----YGVPGFSKDNESLISRAQFLAGVRIGVP 399

  Fly   529 -RPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVF 592
             ..|||..|.:..|.| :.:|...|:|  ||.:..::.|..||.|:.|.....|....|.|.|:|
Mouse   400 QASDLAAEAVVLHYTD-WLHPEDPTHL--RDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIF 461

  Fly   593 GHNSA--TGP-FAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTG 654
            .|.::  |.| :..:||   |.|:.||||.||.     ||.|||.:|::.::.:|.|||||.:||
Mouse   462 EHRASTLTWPLWMGVPH---GYEIEFIFGLPLD-----PSLNYTTEERIFAQRLMKYWTNFARTG 518

  Fly   655 NPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPP-TVGYKYRQIYMNFWNKELPDEL 718
            :|..|            .|.....||.:...||.|:::.:.| .|....|.....|||:.||..|
Mouse   519 DPNDP------------RDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLL 571

  Fly   719 NQIA----------AIQEQLQKPGQEV 735
            :..|          |..|...:||.::
Mouse   572 SATATEAPCTCPSPAHGEAAPRPGPDL 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	190/575 (33%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	59/151 (39%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	190/575 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910