Protein Alignment Nlg1 and CES1

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 648
• Identity: 184/648 - (28%)
• Similarity: 289/648 - (44%)
• Gaps: 115/648 - (17%)

  Fly   122 AAVLATDEGSSEHEPSTTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQ-VDQFL 185
            |.:|||...|:    :...||....||          ....|:::|   :|....|..| |..||
Human     5 AFILATLSASA----AWAGHPSSPPVV----------DTVHGKVLG---KFVSLEGFAQPVAIFL 52

  Fly   186 GLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQK------LPDLSPHGSENMSRARHKHL 244
            |:|:|:.|.|..||.||....||..:|.|...||:|.|.      |.:|..:..||:.
Human    53 GIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIP------- 110

  Fly   245 SRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIV 309
                  |:. ||||||||:|.|.:  .:...:..|:|::||......:.:.|||..|:::..|:|
Human   111 ------LKL-SEDCLYLNIYTPAD--LTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVV 166

  Fly   310 VTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNY 374
            ||:.||||:.||.... |.|:..|:..|||:|||.|:::||.:|||:...||:.|.|.|...|:.
Human   167 VTIQYRLGIWGFFSTG-DEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSV 230

  Fly   375 LMVSPVASGLFHRAILMSGSAMSDWAASNQSLQ-LTMQIAHALECPLNEHVEAEDDDVLLDCLRH 438
            |::||:|..||||||..||.|::........:: |..|||....|      :.....|::.|||.
Human   231 LVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGC------KTTTSAVMVHCLRQ 289

  Fly   439 RRYQDILHIPTALTQFSTS-----------LGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGIT 492
            :..:::|.....:...|..           ||.::||.::...|.::......|...|  :.||.
Human   290 KTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPY--MVGIN 352

  Fly   493 ESESYHTLAALALEEGLRENERDNLLRFYMQSRFDIRPDLALAATL-----KKYQDMYNNPIKAT 552
            :.|....:....:...|.|.:.|.  :..|...:...|.:.:|..|     :||....::.:|
Human   353 KQEFGWLIPMQLMSYPLSEGQLDQ--KTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVK-- 413

  Fly   553 NLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAH--LPHSIM---GEE 612
               .:|:.||:::|.....|.:.....|.|.....|||.|.:..:   |:.  .|.:::   |:|
Human   414 ---KKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPS---FSSDMKPKTVIGDHGDE 472

  Fly   613 LAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDL 677
            |..:||||....|.      :.:|..||:.||.:|.||.:.|||         |...|.
Human   473 LFSVFGAPFLKEGA------SEEEIRLSKMVMKFWANFARNGNP---------NGEGLP------ 516

  Fly   678 DWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQEVITGHM 740
            .|||:|:: :.||.||.......|.:...:.||.       |..|  ::.::||.|   |.|:
Human   517 HWPEYNQK-EGYLQIGANTQAAQKLKDKEVAFWT-------NLFA--KKAVEKPPQ---TEHI 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	166/585 (28%)
		Aes	<263..>408	CDD:223730	54/145 (37%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	168/592 (28%)
		Aes	<122..>240	CDD:223730	45/120 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810